Structural magnetic resonance imaging in dystonia: A systematic review of methodological approaches and findings.
Structural magnetic resonance imaging in dystonia: A systematic review of methodological approaches and findings.
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DOI：
10.1111/ene.15483
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发表时间：
2022-11
影响因子：
5.1
通讯作者：
中科院分区：
文献类型：
--
作者：
结构磁共振技术已广泛应用于神经系统疾病，以更好地了解组织变化，探测体积，铁沉积和扩散等特征。肌张力障碍是一种多动性运动障碍，会导致姿势异常和疼痛。其病理生理机制尚不清楚，常规临床影像学表现为特发性形式。更先进的工具提供了识别可能支持病理生理学的较小规模结构变化的机会。这篇综述的目的是提供在肌张力障碍队列的结构脑成像中所采用的方法学方法的概述，并确定与发病机制有关的常见途径、网络或区域。结构磁共振成像研究的特发性和遗传性形式的肌张力障碍是系统的回顾。遵循严格的纳入和排除标准，PubMed和Embase数据库被检索到2022年1月，并对研究的方法学质量和关键发现进行了审查。纳入77项研究，涉及1945名参与者。大多数研究采用弥散张量成像（DTI） （n = 45）或体积分析（n = 37），经常涉及脑干、小脑、基底神经节和感觉运动皮层及其相互连接的白质通路的异常区域。基因型和运动表型变异出现，例如遗传形式的小脑-丘脑束图流线比特发性的少，任务特异性的灰质体积比非任务特异性的肌张力障碍大。迄今为止的研究表明，被诊断为肌张力障碍的患者的大脑微观结构发生了变化，尽管这些变化的潜在性质仍未确定。采用多重扩散加权或多指数弛豫法等技术有可能增强对这些差异的理解。本文系统综述了结构磁共振成像在肌张力障碍中的应用文献。概述了方法方法和常见的涉及区域。与对照人群相比，关键的灰质运动控制区域及其相互连接的白质最一致地显示出差异。
Structural magnetic resonance techniques have been widely applied in neurological disorders to better understand tissue changes, probing characteristics such as volume, iron deposition and diffusion. Dystonia is a hyperkinetic movement disorder, resulting in abnormal postures and pain. Its pathophysiology is poorly understood, with normal routine clinical imaging in idiopathic forms. More advanced tools provide an opportunity to identify smaller scale structural changes which may underpin pathophysiology. This review aims to provide an overview of methodological approaches undertaken in structural brain imaging of dystonia cohorts, and to identify commonly identified pathways, networks or regions that are implicated in pathogenesis. Structural magnetic resonance imaging studies of idiopathic and genetic forms of dystonia were systematically reviewed. Adhering to strict inclusion and exclusion criteria, PubMed and Embase databases were searched up to January 2022, with studies reviewed for methodological quality and key findings. Seventy‐seven studies were included, involving 1945 participants. The majority of studies employed diffusion tensor imaging (DTI) (n = 45) or volumetric analyses (n = 37), with frequently implicated areas of abnormality in the brainstem, cerebellum, basal ganglia and sensorimotor cortex and their interconnecting white matter pathways. Genotypic and motor phenotypic variation emerged, for example fewer cerebello‐thalamic tractography streamlines in genetic forms than idiopathic and higher grey matter volumes in task‐specific than non‐task‐specific dystonias. Work to date suggests microstructural brain changes in those diagnosed with dystonia, although the underlying nature of these changes remains undetermined. Employment of techniques such as multiple diffusion weightings or multi‐exponential relaxometry has the potential to enhance understanding of these differences. This article systematically reviews the literature applying structural magnetic resonance imaging in dystonia. An overview is provided of methodological approaches and common implicated regions. Key grey matter motor control regions and their interconnecting white matter most consistently demonstrate differences compared to control populations.
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影响因子：
3.7
作者：
Alexandru H;Muthuraman M;Chirumamilla VC;Koirala N;Paktas B;Deuschl G;Zeuner KE;Groppa S
通讯作者：
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作者：
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通讯作者：
May, A
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作者：
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通讯作者：
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通讯作者：
Eidelberg D