Disruption of network for visual perception of natural motion in primary dystonia.
Disruption of network for visual perception of natural motion in primary dystonia.
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DOI：
10.1002/hbm.23907
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发表时间：
2018-03
影响因子：
4.8
通讯作者：
Eidelberg D
中科院分区：
文献类型：
--
作者：
Fujita K;Sako W;Vo A;Bressman SB;Eidelberg D
在健康受试者中，运动区域的大脑活动在视觉感知“自然”目标运动时比在视觉感知“非自然”运动时更活跃，这符合三分之二定律，而非自然运动。目前尚不清楚运动知觉是否正常地由特定的网络调节，该网络可以在疾病背景下改变。我们使用区块设计的功能磁共振成像和协方差分析来识别正常的网络拓扑图，以响应“自然”和“不自然”的运动。在12名健康受试者中发现了一种视觉运动知觉相关模式(VPRP)，其特征是顶下小叶、额盖、枕颞叶外侧皮质、杏仁核和小脑(CRU I)的激活反应不同。在12个来自健康受试者的测试扫描中，证实了在“自然”运动中选择性地激活VPRP。然而，在29名肌张力障碍患者中没有看到持续的网络激活，这是一种可能涉及运动感知通路的神经发育障碍。我们用弥散纤维束造影术评价了VPRP主要结节之间解剖连接的完整性。事实上，在肌张力障碍受试者中，这些通路中的纤维数量显著减少。总而言之，这些发现将正常的运动知觉与离散的大脑网络联系在一起，这一网络在病理条件下可能会被破坏。
In healthy subjects, brain activation in motor regions is greater during the visual perception of “natural” target motion, which complies with the two-thirds power law, than of “unnatural” motion, which does not. It is unknown whether motion perception is normally mediated by a specific network that can be altered in the setting of disease. We used block-design functional magnetic resonance imaging and covariance analysis to identify normal network topographies activated in response to “natural” vs. “unnatural” motion. A visual motion perception-related pattern (VPRP) was identified in 12 healthy subjects, characterized by covarying activation responses in the inferior parietal lobule, frontal operculum, lateral occipitotemporal cortex, amygdala, and cerebellum (Crus I). Selective VPRP activation during “natural” motion was confirmed in 12 testing scans from healthy subjects. Consistent network activation was not seen, however, in 29 patients with dystonia, a neurodevelopmental disorder in which motion perception pathways may be involved. Using diffusion tractography, we evaluated the integrity of anatomical connections between the major VPRP nodes. Indeed, fiber counts in these pathways were substantially reduced in the dystonia subjects. In aggregate, the findings associate normal motion perception with a discrete brain network which can be disrupted under pathological conditions.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
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Peelen, Marius V.
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作者：
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通讯作者：
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