A detailed epidemiological and clinical description of 6 human cases of avian-origin influenza A (H7N9) virus infection in Shanghai.
A detailed epidemiological and clinical description of 6 human cases of avian-origin influenza A (H7N9) virus infection in Shanghai.
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上海6例人感染甲型H7N9流感病毒感染病例的详细流行病学和临床描述
DOI：
10.1371/journal.pone.0077651
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Jie Z
中科院分区：
文献类型：
--
作者：
Shi J;Xie J;He Z;Hu Y;He Y;Huang Q;Leng B;He W;Sheng Y;Li F;Song Y;Bai C;Gu Y;Jie Z
世界首例报告感染H7N9禽流感患者在上海市第五人民医院接受治疗。此后不久，当地又出现了其他几起病例。在此，我们详细介绍了6例H7N9禽流感病例的流行病学和临床资料。我们对上海市闵行区两周内H7N9聚集性感染病例的流行病学和临床资料进行了分析。6例患者中有2例来自单一家族。此外，3名患者有家禽接触史；然而，所有6名患者都居住在2个在鸡和鸽子中检测到H7N9病毒的食品市场附近。主要症状为发热、咳嗽、咯血。在开始时，观察到淋巴细胞计数减少，肌酸激酶、乳酸脱氢酶、降钙素原和C反应蛋白水平升高。随着病情的发展，大多数患者出现呼吸困难和低氧血症。影像检查显示早期有肺实变和多发性毛玻璃样阴影，并迅速向两侧扩散。所有患者在发病后第3-8天开始服用奥司他韦片。主要并发症：急性呼吸窘迫综合征(ARDS)83.3%，继发细菌感染66.7%，胸腔积液50%，左心衰33.3%，神经精神症状33.3%，横纹肌溶解16.7%。6例患者中，4例死于ARDS，2例感染痊愈。上海市闵行区暴发H7N9疫情，极易发展为急性呼吸窘迫综合征。两个病例显示家庭聚集，这使我们确定了H7N9病毒，并表明人类传播可能参与了这种感染的传播。
The world’s first reported patient infected with avian influenza H7N9 was treated at the Fifth People’s Hospital of Shanghai. Shortly thereafter, several other cases emerged in the local area. Here, we describe the detailed epidemiological and clinical data of 6 cases of avian influenza H7N9. We analyzed the epidemiologic and clinical data from clustered patients infected with H7N9 in the Minhang District of Shanghai during a 2-week period. Of the 6 patients, 2 were from a single family. In addition, 3 patients had a history of contact with poultry; however, all 6 patients lived in the proximity of 2 food markets where the H7N9 virus was detected in chickens and pigeons. The main symptoms were fever, cough, and hemoptysis. At onset, a decreased lymphocyte count and elevated creatine kinase, lactate dehydrogenase, procalcitonin, and C-reactive protein levels were observed. As the disease progressed, most patients developed dyspnea and hypoxemia. Imaging studies revealed lung consolidation and multiple ground-glass opacities in the early stage, rapidly extending bilaterally. All patients were treated with oseltamivir tablets beginning on days 3–8 after onset. The main complications were as follows: acute respiratory distress syndrome (ARDS; 83.3%), secondary bacterial infection (66.7%), pleural effusion (50%), left ventricular failure (33.3%), neuropsychiatric symptoms (33.3%), and rhabdomyolysis (16.7%). Of the 6 patients, 4 died of ARDS, with 2 patients recovering from the infection. An outbreak of H7N9 infection occurred in the Minhang District of Shanghai that easily progressed to acute respiratory distress syndrome. Two cases showed family aggregation, which led us to identify the H7N9 virus and indicated that human transmission may be involved in the spread of this infection.
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人类感染新型禽源甲型流感 (H7N9) 病毒。
影响因子：
158.5
作者：
Gao, Rongbao;Cao, Bin;Shu, Yuelong
通讯作者：
Shu, Yuelong
影响因子：
11.8
作者：
Ostrowsky B;Huang A;Terry W;Anton D;Brunagel B;Traynor L;Abid S;Johnson G;Kacica M;Katz J;Edwards L;Lindstrom S;Klimov A;Uyeki TM
通讯作者：
Uyeki TM
影响因子：
12.7
作者：
Wu, Chunli;Lu, Xing;Cheng, Jinquan
通讯作者：
Cheng, Jinquan
影响因子：
168.9
作者：
Yuen, KY;Chan, PKS;Cheng, AFB
通讯作者：
Cheng, AFB
DOI：
10.1016/s0140-6736(04)15595-5
发表时间：
2004-02-21
期刊：
Lancet (London, England)
影响因子：
--
作者：
Peiris JS;Yu WC;Leung CW;Cheung CY;Ng WF;Nicholls JM;Ng TK;Chan KH;Lai ST;Lim WL;Yuen KY;Guan Y
通讯作者：
Guan Y