Oriented Growth of Neural Stem Cell-Derived Neurons Regulated by Magnetic Nanochains.
Oriented Growth of Neural Stem Cell-Derived Neurons Regulated by Magnetic Nanochains.
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DOI：
10.3389/fbioe.2022.895107
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发表时间：
2022
影响因子：
5.7
通讯作者：
Chai, Renjie
中科院分区：
文献类型：
--
作者：
Xia, Lin;Zhang, Chen;Su, Kaiming;Fan, Jiangang;Niu, Yuguang;Yu, Yafeng;Chai, Renjie
神经干细胞治疗已成为治疗神经退行性疾病的一种很有前途的方法。由于神经系统的各向异性，新衍生的神经元不仅需要功能的完整性，而且需要定向生长以与伴侣细胞接触以建立功能连接。因此，新生神经元的定向生长是神经干细胞再生的关键因素。目前，各种生物材料已被应用于辅助神经干细胞来源的神经元定向生长。然而，在这些生物材料中，应用于引导神经元生长的磁性材料仍然较少，如纤维。因此，在这项工作中，我们开发了磁性纳米链来引导神经干细胞来源的神经元定向生长。在磁性纳米链的引导下，种子神经干细胞表现出良好的排列，神经干细胞衍生的神经元也表现出良好的定向生长。我们预计磁性纳米链在基于干细胞的神经再生中具有巨大的潜力。
Neural stem cell therapy has become a promising cure in the treatment of neurodegenerative disorders. Owing to the anisotropy of the nervous system, the newly derived neurons need not only the functional integrity but also the oriented growth to contact with the partner cells to establish functional connections. So the oriented growth of the newly derived neurons is a key factor in neural stem cell–based nerve regeneration. Nowadays, various biomaterials have been applied to assist in the oriented growth of neural stem cell–derived neurons. However, among these biomaterials, the magnetic materials applied in guiding the neuronal growth are still fewer than the other materials, such as the fibers. So in this work, we developed the magnetic nanochains to guide the oriented growth of neural stem cell–derived neurons. With the guidance of the magnetic nanochains, the seeded neural stem cells exhibited a good arrangement, and the neural stem cell–derived neurons showed well-oriented growth with the orientation of the nanochains. We anticipated that the magnetic nanochains would have huge potential in stem cell–based nerve regeneration.
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