The association between early childhood onset epilepsy and attention-deficit hyperactivity disorder (ADHD) in 3237 children and adolescents with Autism Spectrum Disorder (ASD): a historical longitudinal cohort data linkage study.
The association between early childhood onset epilepsy and attention-deficit hyperactivity disorder (ADHD) in 3237 children and adolescents with Autism Spectrum Disorder (ASD): a historical longitudinal cohort data linkage study.
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3237名患有自闭症谱系障碍（ASD）的儿童及青少年中，儿童早期起病癫痫与注意缺陷多动障碍（ADHD）之间的关联：一项历史性纵向队列数据关联研究
DOI：
10.1007/s00787-022-02041-3
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发表时间：
2023-11
影响因子：
6.4
通讯作者：
Downs, Johnny
中科院分区：
文献类型：
--
作者：
Carson, Lauren;Parlatini, Valeria;Safa, Tara;Baig, Benjamin;Shetty, Hitesh;Phillips-Owen, Jacqueline;Prasad, Vibhore;Downs, Johnny
患有自闭症谱系障碍（ASD）的儿童和年轻人患有合并症的风险增加，如癫痫和注意力缺陷/多动症（ADHD）。然而，很少有人知道自闭症儿童早期癫痫（7岁以下）和后来的ADHD诊断（7岁或以上）之间的关系。在这项历史队列研究中，我们使用一种创新的数据源来研究这种关系，其中包括从常规收集的急性医院儿科记录和儿童社区和住院精神病记录中获得的相关数据。在一个大样本的ASD儿童和年轻人（N = 3237）中，我们进行了一项纵向分析，以检查儿童早期癫痫作为ADHD诊断的危险因素，同时调整潜在的混杂因素，包括社会人口特征，智力残疾，癫痫家族史和相关的身体状况。我们发现，ASD儿童和年轻人诊断为儿童早期癫痫的风险增加了近两倍，在以后的生活中发展为ADHD的风险增加了近一倍，在调整潜在的混杂因素后，这种关联仍然存在（调整OR = 1.72，CI 95%= 1.13-2.62）。这项研究表明，对有儿童癫痫史的ASD儿童的ADHD症状进行敏感的监测可能对促进早期发现和治疗很重要。它还强调了如何使用相关的电子健康记录来检查神经发育条件中多Morphine随时间推移的潜在风险因素。在线版本包含补充材料，可通过10.1007/s 00787 -022-02041-3获得。
Children and young people with Autism Spectrum Disorder (ASD) have an increased risk of comorbidities, such as epilepsy and Attention-Deficit/Hyperactivity Disorder (ADHD). However, little is known about the relationship between early childhood epilepsy (below age 7) and later ADHD diagnosis (at age 7 or above) in ASD. In this historical cohort study, we examined this relationship using an innovative data source, which included linked data from routinely collected acute hospital paediatric records and childhood community and inpatient psychiatric records. In a large sample of children and young people with ASD (N = 3237), we conducted a longitudinal analysis to examine early childhood epilepsy as a risk factor for ADHD diagnosis while adjusting for potential confounders, including socio-demographic characteristics, intellectual disability, family history of epilepsy and associated physical conditions. We found that ASD children and young people diagnosed with early childhood epilepsy had nearly a twofold increase in risk of developing ADHD later in life, an association which persisted after adjusting for potential confounders (adjusted OR = 1.72, CI95% = 1.13–2.62). This study suggests that sensitive monitoring of ADHD symptoms in children with ASD who have a history of childhood epilepsy may be important to promote early detection and treatment. It also highlights how linked electronic health records can be used to examine potential risk factors over time for multimorbidity in neurodevelopmental conditions. The online version contains supplementary material available at 10.1007/s00787-022-02041-3.
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影响因子：
10.6
作者：
Amiet, Claire;Gourfinkel-An, Isabelle;Cohen, David
通讯作者：
Cohen, David
影响因子：
3.5
作者：
Fernandes AC;Cloete D;Broadbent MT;Hayes RD;Chang CK;Jackson RG;Roberts A;Tsang J;Soncul M;Liebscher J;Stewart R;Callard F
通讯作者：
Callard F
影响因子：
6.6
作者：
Hayes, Richard D.;Downs, Johnny;Stewart, Robert
通讯作者：
Stewart, Robert
影响因子：
4.7
作者：
Ewen, Joshua B.;Marvin, Alison R.;Lipkin, Paul H.
通讯作者：
Lipkin, Paul H.
影响因子：
2.9
作者：
Downs, Johnny M.;Ford, Tamsin;Hayes, Richard
通讯作者：
Hayes, Richard