Correlation between ABCD, ABCD2 Scores and Craniocervical Artery Stenosis in Patients with Transient Ischemic Attack
Correlation between ABCD, ABCD2 Scores and Craniocervical Artery Stenosis in Patients with Transient Ischemic Attack
复制标题
短暂性脑缺血发作患者ABCD、ABCD2评分与颅颈动脉狭窄的相关性
DOI：
10.1159/000353299
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发表时间：
2013-10
影响因子：
2.4
通讯作者：
Liu XF
中科院分区：
文献类型：
--
作者：
Liu WH;Zhu WS;Xu GL;Liu XF
背景和目的：颅颈动脉狭窄是短暂性脑缺血发作（TIA）的重要病因。我们假设ABCD和ABCD 2评分可以预测TIA患者的颅颈动脉狭窄。研究方法：对南京脑卒中登记项目中479例连续首次TIA患者进行ABCD和ABCD 2评分，并与MRI或有创导管血管造影的血管造影成像进行比较。结果：197例（41.1%）患者发现颅颈动脉（O-CA）全面狭窄。颅外颅颈动脉狭窄101例（21.1%），颅内颅颈动脉狭窄110例（23%）。ABCD和ABCD 2评分对O-CA（AUCABCD 0.71，AUCABCD 2 0.70）、E-CA（AUCABCD 0.72，AUCABCD 2 0.72）和I-CA狭窄（AUCABCD 0.62，AUCABCD 2 0.62）具有相似的准确性，在调整非ABCD 2参数后，两者都是各种动脉狭窄的独立预测因子。两种预测规则的截断点均为4。O-CA/E-CA/I-CA对ABCD的敏感性分别为57.4、65.3和52.7%，特异性分别为77.0、70.4和67.5%。ABCD 2的敏感性分别为61.9%、69.3%和58.2%，特异性分别为72.3%、65.6%和63.1%。结论：在TIA患者中，尽管ABCD和ABCD 2评分与潜在的颅颈动脉狭窄相关，但临床应用受到灵敏度和特异性不满意的限制。
Background and Purpose: Craniocervical artery stenosis is an important etiology for transient ischemic attack (TIA). We hypothesized ABCD and ABCD2 scores can predict craniocervical artery stenosis in patients with TIA. Methods: ABCD and ABCD2 scores were calculated in a total of 479 consecutive first-ever TIA patients in Nanjing Stroke Registry Program and compared with angiographic imaging derived from MRI or invasive catheter-based angiography. Results: Overall craniocervical artery (O-CA) stenosis was found in 197 (41.1%) patients. Extracranial craniocervical artery (E-CA) and intracranial craniocervical artery (I-CA) stenosis was found in 101 (21.1%) and 110 (23%) cases, respectively. ABCD and ABCD2 scores with similar accuracy for O-CA (AUCABCD 0.71, AUCABCD2 0.70), E-CA (AUCABCD 0.72, AUCABCD2 0.72) and I-CA stenosis (AUCABCD 0.62, AUCABCD2 0.62) were both independent predictors for various categories of artery stenosis after being adjusted for non-ABCD2 parameters. The cut-off points were equally 4 in both predicting rules. For ABCD, sensitivity was 57.4, 65.3 and 52.7% and specificity 77.0, 70.4 and 67.5% for O-CA/E-CA/I-CA, respectively. For ABCD2, sensitivity was 61.9, 69.3 and 58.2% and specificity 72.3, 65.6 and 63.1%. Conclusions: In patients with TIA, despite an association between ABCD and ABCD2 scores and underlying craniocervical artery stenosis, the clinical utility was limited by unsatisfactory sensitivity and specificity.
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影响因子：
8.3
作者：
Khan A;Kasner SE;Lynn MJ;Chimowitz MI;Warfarin Aspirin Symptomatic Intracranial Disease (WASID) Trial Investigators
通讯作者：
Warfarin Aspirin Symptomatic Intracranial Disease (WASID) Trial Investigators
影响因子：
19.7
作者：
Randoux, B;Marro, B;Marsault, C
通讯作者：
Marsault, C
影响因子：
8.3
作者：
Sheehan, Orla C.;Kyne, Lorraine;Kelly, Peter J.
通讯作者：
Kelly, Peter J.
影响因子：
168.9
作者：
Johnston, S. Claiborne;Rothwell, Peter M.;Sidney, Stephen
通讯作者：
Sidney, Stephen
影响因子：
158.5
作者：
Inzitari, D;Eliasziw, M;Barnett, HJM
通讯作者：
Barnett, HJM