Role of recBC function in formation of chromosomal rearrangements: a two-step model for recombination.
Role of recBC function in formation of chromosomal rearrangements: a two-step model for recombination.
复制标题
recBC 功能在染色体重排形成中的作用:重组的两步模型。
DOI:
10.1093/genetics/121.3.433
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发表时间:
1989
期刊:
影响因子:
3.3
通讯作者:
Roth,JR
中科院分区:
文献类型:
--
作者:
Mahan,MJ;Roth,JR
The role of recBC functions has been tested for three types of chromosomal recombination events: (1) recombination between direct repeats to generate a deletion, (2) recombination between a small circular fragment and the chromosome, and (3) recombination between inversely oriented repeats to form an inversion. Deletion formation by recombination between direct repeats, which does not require a fully reciprocal exchange, is independent of recBC function. Circle integration and inversion formation are both stimulated by the recBC function; these events require full reciprocality. The results suggest that half-reciprocal exchanges can occur without recBC, but recBC functions greatly stimulate completion of a fully reciprocal exchange. We propose that chromosomal recombination is a two-step process, and recBC functions are primarily required for the second step.
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影响因子:
3.3
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通讯作者:
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DOI:
--
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1959
期刊:
影响因子:
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