Epigenetic regulation of natural killer cell memory.
Epigenetic regulation of natural killer cell memory.
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DOI：
10.1111/imr.13031
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发表时间：
2022-01
影响因子：
8.7
通讯作者：
Sun JC
中科院分区：
文献类型：
--
作者：
Lau CM;Wiedemann GM;Sun JC
Immunologic memory is the underlying mechanism by which the immuno system remembers previous encounters with pathogens to produce an enhanced secondary response upon re-encounter. It stands as the hallmark feature of the adaptive immuno system and the cornerstone of vaccine development. Classic recall responses are executed by conventional T and B cells, which undergo somatic recombination and modify their receptor repertoire to ensure recognition of a vast number of antigens. However, recent有证据表明，教条的记忆反应仅限于适应性免疫系统，这促使对天生免疫系统的“免疫记忆”（NK）细胞的描述重新评估。这篇综述，我们讨论了效应子和记忆NK细胞反应所需的许多信号以及最终赋予其增强特征的表观遗传机制。
Immunological memory is the underlying mechanism by which the immune system remembers previous encounters with pathogens to produce an enhanced secondary response upon re-encounter. It stands as the hallmark feature of the adaptive immune system and the cornerstone of vaccine development. Classic recall responses are executed by conventional T and B cells, which undergo somatic recombination and modify their receptor repertoire to ensure recognition of a vast number of antigens. However, recent evidence has challenged the dogma that memory responses are restricted to the adaptive immune system, which has prompted a reevaluation of what delineates “immune memory.” Natural killer (NK) cells of the innate immune system have been at the forefront of these pushed boundaries, and have proved to be more “adaptable” than previously thought. Like T cells, we now appreciate that their “natural” abilities actually require a myriad of signals for optimal responses. In this review, we discuss the many signals required for effector and memory NK cell responses and the epigenetic mechanisms that ultimately endow their enhanced features.
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
7.3
作者：
Bhatt D;Ghosh S
通讯作者：
Ghosh S
DOI：
10.4049/jimmunol.1003173
发表时间：
2011-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ishihara S;Schwartz RH
通讯作者：
Schwartz RH
DOI：
10.1084/jem.187.5.813
发表时间：
1998-03-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Borrego F;Ulbrecht M;Weiss EH;Coligan JE;Brooks AG
通讯作者：
Brooks AG
影响因子：
7.3
作者：
Bailey CP;Figueroa M;Gangadharan A;Lee DA;Chandra J
通讯作者：
Chandra J