The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection.
The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection.
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自然杀伤（NK）细胞是先天淋巴细胞，表现出许多适应性免疫特征，包括克隆增殖和长效记忆。在这里，我们证明了BTB-ZF转录因子Zbtb 32（也称为ROG，FAZF，TZFP和PLZP）对于病毒特异性NK细胞的增殖爆发和保护能力至关重要。来自促炎细胞因子的信号对于诱导NK细胞中的高Zbtb 32表达是必要的且足够的。从机制上讲，我们发现Zbtb 32通过拮抗抗增殖因子Blimp-1（Prdm 1）促进感染期间NK细胞增殖。综上所述，我们的数据支持Zbtb 32作为细胞“枢纽”的模型，通过该模型，促炎信号指示NK细胞的“增殖许可”状态，从而允许它们响应病毒感染而大量扩增。
Natural Killer (NK) cells are innate lymphocytes that exhibit many features of adaptive immunity including clonal proliferation and long-lived memory. Here we demonstrate that the BTB-ZF transcription factor Zbtb32 (also known as ROG, FAZF, TZFP, and PLZP) is essential for the proliferative burst and protective capacity of virus-specific NK cells. Signals from proinflammatory cytokines are both necessary and sufficient to induce high Zbtb32 expression in NK cells. Mechanistically, we show that Zbtb32 facilitates NK cell proliferation during infection by antagonizing the anti-proliferative factor Blimp-1 (Prdm1). Taken together, our data support a model in which Zbtb32 acts as a cellular “hub” through which pro-inflammatory signals instruct a “proliferation-permissive” state in NK cells, thereby allowing their prolific expansion in response to viral infection.
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
56.9
作者：
Brown, MG;Dokun, AO;Yokoyama, WM
通讯作者：
Yokoyama, WM
影响因子：
64.8
作者：
He, X;He, X;Kappes, DJ
通讯作者：
Kappes, DJ
影响因子：
32.4
作者：
Miaw, SC;Choi, A;Ho, IC
通讯作者：
Ho, IC
DOI：
10.4049/jimmunol.1004006
发表时间：
2011-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Beaulieu AM;Sant'Angelo DB
通讯作者：
Sant'Angelo DB