Prevention of melanin formation by yeast cerebroside in B16 mouse melanoma cells.
Prevention of melanin formation by yeast cerebroside in B16 mouse melanoma cells.
复制标题
酵母脑苷脂在 B16 小鼠黑色素瘤细胞中预防黑色素形成。
作者：
M. Kinoshita;N. Hori;K. Aida;T. Sugawara;M. Ohnishi
在B16小鼠黑色素瘤细胞中检测了植物和酵母糖苷对黑色素形成的影响。添加酵母胞苷显着降低黑色素含量的相同水平的熊果苷在控制细胞，虽然没有抑制植物胞苷和牛脑胞苷上调黑色素的形成。牛脑苷脂对酪氨酸酶活性无影响，酵母苷脂可降低酪氨酸酶含量。本研究的结果清楚地表明，黑色素的形成是由几种不同的糖苷通过酪氨酸酶调节的。此外，本文提出的发现表明，含有9-甲基型鞘氨醇碱的β-葡糖苷，如酵母β-葡糖苷，可用作抑制黑色素形成的护肤产品。
The effects of plant and yeast cerebrosides on melanin formation were examined in B16 mouse melanoma cells. Addition of yeast cerebroside significantly reduced melanin content to the same level as that of arbutin in control cells, although there was no suppression by plant cerebrosides and bovine brain cerebroside up-regulated melanin formation. None of the bovine brain cerebrosides examined had any effect on tyrosinase activity, but yeast cerebroside reduced the contents of tyrosinase. The results of the present study clearly showed that melanin formation is regulated by several different cerebrosides via tyrosinase. In addition, the findings presented here suggest that cerebrosides containing a 9-methyl type sphingoid base, such as yeast cerebroside, may be useful as skincare products for suppressing melanin formation.
影响因子：
3.5
作者：
JI, L;ZHANG, G;HIRABAYASHI, Y
通讯作者：
HIRABAYASHI, Y