Chromosome jumping from flanking markers defines the minimal region for alf/hsdr-1 within the albino-deletion complex.
Chromosome jumping from flanking markers defines the minimal region for alf/hsdr-1 within the albino-deletion complex.
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从侧翼标记的染色体跳跃定义了白化缺失复合体中 alf/hsdr-1 的最小区域。
DOI：
10.1016/s0888-7543(05)80218-6
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发表时间：
1992
期刊：
影响因子：
4.4
通讯作者：
Schütz,G
中科院分区：
文献类型：
--
作者：
Schedl,A;Ruppert,S;Kelsey,G;Thies,E;Niswander,L;Magnuson,T;Klebig,ML;Rinchik,EM;Schütz,G
The locusalf/hsdr-1, defined by the albino-deletion complex on mouse chromosome 7, is essential for neonatal survival. Animals homozygous for a subset of the deletions die shortly after birth due to impaired gene expression in liver parenchymal cells and kidney proximal tubular cells. Here, we describe a detailed analysis of the region containingalf/hsdr-1by means of chromosome jumping from flanking markers. Three chromosome jumping libraries based on the restriction enzymesXmaI andSalI were constructed. Isolation of eight jumping clones distributed over 450 kb allowed more than 240 kb to be cloned in genomic λ and cosmid libraries. Five of the probes map within the minimal genetic interval foralf/hsdr-1, which is defined by the proximal borders of the deletionsc10R75Mandc11DSD. The breakpoints of these deletions were precisely mapped, which allowedalf/hsdr-1to be localized to a 310-kb interval.
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影响因子：
9.8
作者：
Daniel Phaneuf;Yves Labelle;D. Bérubé;Karen C. Arden;Webster Cavenee;Richard Gagné;Robert M. Tanguay
通讯作者：
Daniel Phaneuf;Yves Labelle;D. Bérubé;Karen C. Arden;Webster Cavenee;Richard Gagné;Robert M. Tanguay
影响因子：
--
作者：
G. Pfeifer;A. Riggs
通讯作者：
G. Pfeifer;A. Riggs
对小鼠白化缺失复合物进行物理定位，以定位 alf/hsdr-1（新生儿存活所需的基因座）。
影响因子：
4.4
作者：
Kelsey,G;Schedl,A;Ruppert,S;Niswander,L;Magnuson,T;Klebig,ML;Rinchik,EM;Schütz,G
通讯作者：
Schütz,G
人类 PI 和 AACT 基因的物理图谱。
影响因子：
4.4
作者：
Louise Sefton;Gavin Kelsey;Phillip Kearney;S. Povey;Jonathan Wolfe
通讯作者：
Jonathan Wolfe
染色体从 D4S10 (G8) 跳跃到亨廷顿病基因。
DOI：
10.1073/pnas.85.17.6437
发表时间：
1988
影响因子：
11.1
作者：
Richards,JE;Gilliam,TC;Cole,JL;Drumm,ML;Wasmuth,JJ;Gusella,JF;Collins,FS
通讯作者：
Collins,FS