Childhood environment influences adrenarcheal timing among first-generation Bangladeshi migrant girls to the UK.
Childhood environment influences adrenarcheal timing among first-generation Bangladeshi migrant girls to the UK.
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DOI：
10.1371/journal.pone.0109200
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Bentley GR
中科院分区：
文献类型：
--
作者：
Houghton LC;Cooper GD;Booth M;Chowdhury OA;Troisi R;Ziegler RG;Katki HA;Hoover RN;Bentley GR
肾上腺素亢进是一个关键的早期生活事件，标志着大约7岁时的童年中期。早期对英国-孟加拉国移民妇女的研究表明，肾上腺素上升前的环境条件会影响成年后的生殖功能。因此，我们调查了移民到英国的孟加拉国儿童是否比孟加拉国或英国的非移民儿童更早达到肾上腺素亢进。从孟加拉国锡尔赫特和英国伦敦的学校招募了5-16岁的健康女孩，包括四组：锡尔赫特人（n = 165）、第一代英国移民（n = 42）、第二代女孩（n = 162）和欧洲裔英国女孩（n = 50）。人体测量数据与移民和社会经济特征的问卷数据一起收集。采用酶联免疫吸附法检测唾液样品中的脱氢表雄酮（DHEAS）。多元线性回归测试了人体测量和社会经济变量以及DHEAS水平的组差异。使用威布尔回归模型进行参数生存分析，估计肾上腺皮质激素的中位年龄（DHEAS>400 pg/ml）。从生存分析中估计未调整和调整人体测量变量的早期达到肾上腺素的风险比和95%置信区间（CI）。第一代移民的平均肾上腺年龄（5.3岁）明显早于Sylheti女孩（7.2岁）、第二代移民女孩（7.4岁）和欧洲女孩（7.1岁）。在单变量分析中，第一代女孩明显早于男孩达到肾上腺素峰值[HR (CI): 2.8(1.4-5.5)]。在多变量模型中，调整身高[HR(CI): 1.9(0.9-4.1)]和体重[HR(CI):1.7(0.8-3.8)]后，第一代女孩仍比Sylhetis早到达肾上腺素，但结果有所减弱。我们认为，第一代女孩在童年早期经历的快速追赶成长可能解释了她们的肾上腺素水平较高。导致肾上腺素早期发作的环境条件，以及这种早期转变对健康的影响，值得进一步探索。
Adrenarche is a key early life event that marks middle childhood at approximately 7 years of age. Earlier work with British-Bangladeshi migrant women suggested that environmental conditions experienced before adrenarche influence adult reproductive function. We therefore investigated whether Bangladeshi children who migrate to the United Kingdom (UK) reach adrenarche earlier than non-migrants in Bangladesh or the United Kingdom. Healthy girls, aged 5–16 years, were recruited from schools in Sylhet, Bangladesh and London, England comprising four groups: Sylhetis (n = 165), first-generation migrants to the United Kingdom (n = 42), second-generation girls (n = 162), and British girls of European origin (n = 50). Anthropometric measurements were collected together with questionnaire data for migration and socioeconomic characteristics. Saliva samples were assayed for dehydroepiandrosterone (DHEAS) using enzyme-linked immunosorbent assays. Multiple linear regressions tested for group differences in anthropometric and socioeconomic variables and DHEAS levels. Median ages at adrenarche (DHEAS>400 pg/ml) were estimated using Weibull regression models for parametric survival analysis. Hazard ratios for reaching adrenarche earlier and 95% confidence intervals (CI), both unadjusted and adjusted for anthropometric variables, were estimated from the survival analyses. First-generation migrants had a median age at adrenarche (5.3 years) that was significantly earlier than Sylheti (7.2), second-generation (7.4), and European (7.1) girls. In univariate analyses, first-generation girls reached adrenarche significantly earlier than Sylhetis [HR (CI): 2.8 (1.4–5.5]. In multivariate models, first generation girls still reached adrenarche earlier than Sylhetis after adjusting for height [HR(CI): 1.9 (0.9–4.1)] and weight [HR(CI):1.7 (0.8–3.8)], but these results were attenuated. We suggest that rapid catch-up growth experienced by first generation girls during early childhood may explain their advanced adrenarche. The environmental conditions leading to an earlier adrenarche, as well as the health implications of this early transition, merit further exploration.
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影响因子：
5.8
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