Ketamine disrupts gaze patterns during face viewing in the common marmoset
Ketamine disrupts gaze patterns during face viewing in the common marmoset
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氯胺酮会扰乱普通狨猴在观察面部时的凝视模式
DOI：
10.1101/2021.02.16.431438
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
S. Everling
中科院分区：
文献类型：
--
作者：
Janahan Selvanayagam;K. Johnston;R. Wong;D. Schaeffer;S. Everling
面孔对灵长类动物来说是至关重要的刺激。普通的绒猴（Callithrix jacchus）是一个很有前途的模型，用于调查的脸处理，因为这个物种拥有类似于猕猴和人类的眼和脸处理网络。面孔处理在精神分裂症（SZ）等神经精神疾病中经常被破坏，因此在临床前重述潜在的电路功能障碍是很重要的。N-甲基-D-天冬氨酸（NMDA）非竞争性拮抗剂氯胺酮已被广泛用于模拟SZ的认知症状。在这里，我们研究了亚麻醉剂量的氯胺酮对猕猴在看脸过程中的眼部行为的影响。四只绒猴接受了全身氯胺酮或盐水注射，同时观看同种面部的相位扰乱或完整视频。为了评估氯胺酮在面部观察期间对扫描路径的影响，我们确定了每个面部视频中的感兴趣区域，并对这些区域内的扫视起始位置和着陆位置进行了分类。氯胺酮给药后，观察到鼻部优于眼部区域。此外，眼跳着陆的区域可以通过盐水中的眼跳起始区域而不是氯胺酮条件下的眼跳起始区域来显著预测。对于相位加扰视频，未观察到显著的药物效应。对扫视控制的影响仅限于在观看加扰视频期间扫视幅度的减少。因此，氯胺酮诱导了一个显着的破坏扫描路径在观看同种面孔，但有限的影响扫视电机控制。这些发现支持使用氯胺酮在绒猴中研究神经回路的变化，这些神经回路是神经精神疾病中社会认知的基础。
Faces are stimuli of critical importance for primates. The common marmoset (Callithrix jacchus) is a promising model for investigations of face processing, as this species possesses oculomotor and face processing networks resembling those of macaques and humans. Face processing is often disrupted in neuropsychiatric conditions such as schizophrenia (SZ) and thus it is important to recapitulate underlying circuitry dysfunction preclinically. The N-Methyl-D-aspartate (NMDA) non-competitive antagonist ketamine has been used extensively to model the cognitive symptoms of SZ. Here, we investigated the effects of a subanesthetic dose of ketamine on oculomotor behaviour in marmosets during face viewing. Four marmosets received systemic ketamine or saline injections while viewing phase-scrambled or intact videos of conspecifics’ faces. To evaluate effects of ketamine on scan paths during face viewing, we identified regions of interest in each face video, and classified locations of saccade onsets and landing positions within these areas. A preference for the snout over eye regions was observed following ketamine administration. In addition, regions in which saccades landed could be significantly predicted by saccade onset region in the saline but not the ketamine condition. No significant drug effects were observed for phase-scrambled videos. Effects on saccade control were limited to a reduction in saccade amplitudes during viewing of scrambled videos. Thus, ketamine induced a significant disruption of scan paths during viewing of conspecific faces but limited effects on saccade motor control. These findings support the use of ketamine in marmosets for investigating changes in neural circuits underlying social cognition in neuropsychiatric disorders.
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影响因子：
1.8
作者：
Li Yi;Yuebo Fan;P. Quinn;Cong Feng;Dan Huang;Jiao Li;Guoquan Mao;Kang Lee
通讯作者：
Li Yi;Yuebo Fan;P. Quinn;Cong Feng;Dan Huang;Jiao Li;Guoquan Mao;Kang Lee
影响因子：
6.6
作者：
Lundin NB;Sepe-Forrest L;Gilbert JR;Carver FW;Furey ML;Zarate CA Jr;Nugent AC
通讯作者：
Nugent AC
氯胺酮对情绪处理过程中大脑活动的影响：抑郁症参与者与健康对照组参与者的差异发现。
DOI：
10.1016/j.bpsc.2019.01.005
发表时间：
2019
期刊：
Biological psychiatry. Cognitive neuroscience and neuroimaging
影响因子：
--
作者：
Reed,JessicaL;Nugent,AllisonC;Furey,MauraL;Szczepanik,JoannaE;Evans,JenniferW;ZarateJr,CarlosA
通讯作者：
ZarateJr,CarlosA
影响因子：
--
作者：
KRYSTAL, JH;KARPER, LP;CHARNEY, DS
通讯作者：
CHARNEY, DS