Ketamine Alters Electrophysiological Responses to Emotional Faces in Major Depressive Disorder.
Ketamine Alters Electrophysiological Responses to Emotional Faces in Major Depressive Disorder.
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DOI：
10.1016/j.jad.2020.10.007
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发表时间：
2021-01-15
影响因子：
6.6
通讯作者：
Nugent AC
中科院分区：
文献类型：
--
作者：
Lundin NB;Sepe-Forrest L;Gilbert JR;Carver FW;Furey ML;Zarate CA Jr;Nugent AC
多巴胺能调节剂氯胺酮可迅速减轻难治性重度抑郁症（MDD）患者的抑郁症状。然而，氯胺酮对情绪处理偏差的影响在很大程度上仍然未知，了解这些过程可能有助于阐明氯胺酮的作用机制。采用脑磁图（MEG）研究氯胺酮对MDD患者（n=31）和健康志愿者（HV; n=24）对情感刺激的早期视觉反应的影响。参与者参加了一项双盲、安慰剂对照、交叉临床试验，并在基线和亚麻醉剂量氯胺酮和安慰剂盐水输注后进行评估。在MEG记录过程中，参与者完成了一项情绪评估任务，其中他们指出了面部刺激的性别或情绪效价（快乐中性或悲伤愤怒）。从感兴趣区域提取源定位事件相关场（ERF）M100和M170振幅和振幅。线性固定效应模型研究诊断，刺激效价，和药物会话的行为和MEG数据之间的相互作用。在基线行为分析中，MDD参与者对悲伤-愤怒的面孔比快乐中性面孔表现出更高的准确性，而HV对快乐中性面孔的反应比悲伤-愤怒面孔更快。在输注后MEG分析中，MDD中的钙钛矿M100振幅大于安慰剂后HV受试者，但在氯胺酮后变得更加相似。最后，梭状M170振幅与MDD参与者的抗抑郁反应相关。由于样本量有限，而且为了增加统计功效，需要对快乐和中性面孔的反应进行分解，这限制了研究结果的普遍性。氯胺酮迅速改变了MDD患者的情绪刺激处理，为未来研究抗抑郁治疗反应的生物标志物奠定了基础。Clinicaltrials.gov，NCT#00088699
The glutamatergic modulator ketamine rapidly reduces depressive symptoms in individuals with treatment-resistant major depressive disorder (MDD). However, ketamine’s effects on emotional processing biases remain largely unknown, and understanding these processes may help elucidate ketamine’s mechanism of action. Magnetoencephalography (MEG) was used to investigate ketamine’s effects on early visual responses to affective stimuli in individuals with MDD (n=31) and healthy volunteers (HVs; n=24). Participants were enrolled in a double-blind, placebo-controlled, crossover clinical trial and were assessed at baseline and after subanesthetic-dose ketamine and placebo-saline infusions. During MEG recording, participants completed an emotional evaluation task in which they indicated the sex or emotional valence (happy-neutral or sad-angry) of facial stimuli. Source-localized event-related field (ERF) M100 and M170 amplitudes and latencies were extracted from regions of interest. Linear fixed effects models examined interactions between diagnosis, stimulus valence, and drug session for behavioral and MEG data. In baseline behavioral analyses, MDD participants exhibited higher accuracy for sad-angry than happy-neutral faces, and HVs responded faster to happy-neutral than sad-angry faces. In the MEG post-infusion analyses, calcarine M100 amplitudes were larger in MDD than HV participants post-placebo but became more similar post-ketamine. Finally, fusiform M170 amplitudes were associated with antidepressant response in MDD participants. The modest sample size and the need to collapse across responses to happy and neutral faces to increase statistical power limit the generalizability of the findings. Ketamine rapidly altered emotional stimulus processing in MDD, laying the groundwork for future investigations of biomarkers of antidepressant treatment response. Clinicaltrials.gov, NCT#00088699
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影响因子：
6.9
作者：
Fritzsche, A.;Dahme, B.;Gotlib, I. H.;Joormann, J.;Magnussen, H.;Watz, H.;Nutzinger, D. O.;von Leupoldt, A.
通讯作者：
von Leupoldt, A.
影响因子：
11
作者：
Fava M;Freeman MP;Flynn M;Judge H;Hoeppner BB;Cusin C;Ionescu DF;Mathew SJ;Chang LC;Iosifescu DV;Murrough J;Debattista C;Schatzberg AF;Trivedi MH;Jha MK;Sanacora G;Wilkinson ST;Papakostas GI
通讯作者：
Papakostas GI
影响因子：
3
作者：
Dai, Qin;Feng, Zhengzhi;Koster, Ernst H. W.
通讯作者：
Koster, Ernst H. W.
DOI：
10.4088/jcp.09m05327blu
发表时间：
2010-12
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
DiazGranados N;Ibrahim LA;Brutsche NE;Ameli R;Henter ID;Luckenbaugh DA;Machado-Vieira R;Zarate CA Jr
通讯作者：
Zarate CA Jr
影响因子：
11.3
作者：
GUR, RC;ERWIN, RJ;KRAEMER, HC
通讯作者：
KRAEMER, HC