Imaging of dopamine D2/3 agonist binding in cocaine dependence: a [11C]NPA positron emission tomography study.
Imaging of dopamine D2/3 agonist binding in cocaine dependence: a [11C]NPA positron emission tomography study.
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DOI：
10.1002/syn.20970
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发表时间：
2011-12
期刊：
影响因子：
2.3
通讯作者：
Frankle, W. Gordon
中科院分区：
文献类型：
--
作者：
Narendran, Rajesh;Martinez, Diana;Mason, Neale Scott;Lopresti, Brian J.;Himes, Michael L.;Chen, Chi-Min;May, Maureen A.;Price, Julie C.;Mathis, Chester A.;Frankle, W. Gordon
关键词：
PET studies performed with [11C]raclopride have consistently reported lower binding to D2/3 receptors and lower amphetamine-induced dopamine release in cocaine abusers relative to healthy controls. A limitation of these studies that were performed with D2/3 antagonist radiotracers such as [11C]raclopride is the failure to provide information that is specific to D2/3 receptors configured in a state of high affinity for the agonists (i.e., D2/3 receptors coupled to G- proteins, D2/3 HIGH). As the endogenous agonist dopamine binds with preference to D2/3 HIGH relative to D2/3 LOW receptors (i.e., D2/3 receptors uncoupled to G-proteins) it is critical to understand the in vivo status of D2/3 HIGH receptors in cocaine dependence. Thus, we measured the available fraction of D2/3 HIGH receptors in 10 recently abstinent cocaine abusers (CD) and matched healthy controls (HC) with the D2/3 antagonist and agonist PET radiotracers [11C]raclopride and [11C]NPA [11C]raclopride and [11C]NPA binding potential (BPND) in the striatum were measured with kinetic analysis using the arterial input function. The available fraction of D2/3 HIGH receptors, i.e., % RHIGH available=D2/3 HIGH/(D2/3 HIGH + D2/3 LOW) was then computed as the ratio of [11C]NPA BPND/[11C]raclopride BPND. No differences in striatal [11C]NPA BPND (HC = 1.00 ± 0.17; CD = 0.97 ± 0.17, p =0.67) or available % RHIGH (HC= 39% ± 5%; CD = 41% ± 5%, p = 0.50) was observed between cocaine abusers and matched controls The results of this [11C]NPA PET study do not support alterations in D2/3 HIGH binding in the striatum in cocaine dependence.
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影响因子：
2.3
作者：
Narendran, R;Hwang, DR;Laruelle, M
通讯作者：
Laruelle, M
影响因子：
3.1
作者：
Hwang, DR;Kegeles, LS;Laruelle, M
通讯作者：
Laruelle, M
影响因子：
2.3
作者：
Narendran, Rajesh;Frankle, W. Gordon;Mathis, Chester A.
通讯作者：
Mathis, Chester A.
影响因子：
2.3
作者：
Seeman, P;Tallerico, T;Kapur, S
通讯作者：
Kapur, S
影响因子：
3.8
作者：
GANDELMAN, MS;BALDWIN, RM;INNIS, RB
通讯作者：
INNIS, RB