Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2.
Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2.
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作者：
年轻女性乳腺癌的预后受生育史的影响。产后五年内确诊的妇女比未分娩的妇女或怀孕期间确诊的妇女预后更差。在这里，我们描述了一个产后乳腺癌的小鼠模型，该模型确定乳腺退化是肿瘤进展的驱动力。在这个模型中，暴露在消退的乳腺微环境中的人乳腺癌细胞形成大的肿瘤，其特征是丰富的纤维胶原，高表达的COX-2和侵袭性表型。在培养中，肿瘤细胞以纤维状胶原和COX-2依赖的方式侵袭。在消退的乳腺中，COX-2的抑制减少了与消退相关的胶原纤维形成，以及肿瘤的生长和肿瘤细胞对肺的侵袭。这些数据支持进一步的研究，以确定产后乳腺癌高危女性是否会从产后消退期间使用非类固醇抗炎药的治疗中受益。
Prognosis of young women’s breast cancer is influenced by reproductive history. Women diagnosed within five years postpartum have worse prognosis than nulliparous women or women diagnosed during pregnancy. Here we describe a mouse model of postpartum breast cancer that identifies mammary gland involution as a driving force of tumor progression. In this model, human breast cancer cells exposed to the involuting mammary microenvironment form large tumors characterized by abundant fibrillar collagen, high COX-2 expression, and an invasive phenotype. In culture, tumor cells are invasive in a fibrillar collagen and COX-2-dependent manner. In the involuting mammary gland, inhibition of COX-2 reduces the collagen fibrillogenesis associated with involution, as well as tumor growth and tumor cell infiltration to the lung. These data support further research to determine whether women at high-risk for postpartum breast cancer would benefit from treatment with NSAIDs during postpartum involution.
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DOI：
10.1186/bcr1678
发表时间：
2007
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Howe LR
通讯作者：
Howe LR
影响因子：
6.2
作者：
Denkert, C;Winzer, KJ;Hauptmann, S
通讯作者：
Hauptmann, S
影响因子：
2.3
作者：
Kwan, Marilyn L.;Habel, Laurel A.;Caan, Bette
通讯作者：
Caan, Bette
影响因子：
11.2
作者：
Gupta, Piyush B.;Proia, David;Kuperwasser, Charlotte
通讯作者：
Kuperwasser, Charlotte
影响因子：
6
作者：
Conklin, Matthew W.;Eickhoff, Jens C.;Keely, Patricia J.
通讯作者：
Keely, Patricia J.