Prognostic value of left ventricular-arterial coupling estimated using echocardiography in dogs with myxomatous mitral valve disease.
Prognostic value of left ventricular-arterial coupling estimated using echocardiography in dogs with myxomatous mitral valve disease.
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DOI：
10.1111/jvim.16290
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发表时间：
2021-11
影响因子：
2.6
通讯作者：
Takiguchi M
中科院分区：
文献类型：
--
作者：
Osuga T;Morita T;Sasaki N;Morishita K;Ohta H;Takiguchi M
根据有效动脉弹性（Ea）与LV收缩末期弹性（Ees）比值（Ea/Ees），评价了左心室（LV）和全身动脉系统之间的相互作用，称为左心室-动脉耦合（VAC）。Ea反映左室总动脉负荷，Ees反映左室收缩功能。最近的一项研究发现，基于超声心动图估计的Ea/Ees增加的不适当VAC与患有粘液瘤性二尖瓣疾病（MMVD）的犬的晚期疾病严重程度相关。通过超声心动图估计Ea/Ees评估的不适当VAC与MMVD犬的预后不良相关。89只患MMVD的犬前瞻性队列研究。犬在入组时接受超声心动图检查。使用公式估计Ea：平均血压/（前向每搏输出量/体重）。使用公式估计Ees：平均血压/（LV收缩末期容积/体重）。计算Ea/Ees。研究结束时，22只犬死于心脏相关原因，67只犬被删失。Ea/Ees增加的犬（Ea/Ees> 0.34;中位生存时间，527天; 95%置信区间[CI]，322天-无法确定）的生存时间短于Ea/Ees未增加的犬（Ea/Ees ≤ 0.34;中位生存时间，> 1112天; 95% CI，无法确定）（P <.0001）。多变量考克斯比例风险分析显示，Ea/Ees、体重、二尖瓣环收缩期峰值速度和二尖瓣环舒张早期峰值速度与二尖瓣环舒张早期峰值速度比是超声心动图指标中心脏相关死亡的独立预测因素。基于超声心动图估计的Ea/Ees评估的不适当VAC与MMVD犬的预后较差相关。
The interaction between the left ventricle (LV) and systemic arterial systems, known as left ventricular‐arterial coupling (VAC), has been evaluated based on the effective arterial elastance (Ea) to LV end‐systolic elastance (Ees) ratio (Ea/Ees). The Ea reflects the total arterial load of LV, whereas Ees reflects the LV systolic function. A recent study found that inappropriate VAC based on increased Ea/Ees estimated by echocardiography is associated with advanced disease severity in dogs with myxomatous mitral valve disease (MMVD). Inappropriate VAC assessed by echocardiographic estimation of Ea/Ees is associated with a worse prognosis in dogs with MMVD. Eighty‐nine dogs with MMVD. Prospective cohort study. Dogs underwent echocardiographic examinations at enrollment. The Ea was estimated using the formula: mean blood pressure/(forward stroke volume/body weight). The Ees was estimated using the formula: mean blood pressure/(LV end‐systolic volume/body weight). The Ea/Ees was calculated. By end of study, 22 dogs died of cardiac‐related causes with 67 dogs censored. Dogs with increased Ea/Ees (Ea/Ees >0.34; median survival time, 527 days; 95% confidence interval [CI], 322 days‐not determinable) had a shorter survival time (P < .0001) than those without increased Ea/Ees (Ea/Ees ≤0.34; median survival time, >1112 days; 95% CI, not determinable). Multivariate Cox proportional hazard analysis showed that Ea/Ees, body weight, peak systolic mitral annular velocity, and the peak early diastolic transmitral velocity‐to‐peak early diastolic mitral annular velocity ratio were independent predictors of cardiac‐related death among echocardiographic indices. Inappropriate VAC assessed based on echocardiographically‐estimated Ea/Ees is associated with a worse prognosis in dogs with MMVD.
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影响因子：
2.6
作者：
Rasmussen CE;Falk T;Domanjko Petrič A;Schaldemose M;Zois NE;Moesgaard SG;Ablad B;Nilsen HY;Ljungvall I;Höglund K;Häggström J;Pedersen HD;Bland JM;Olsen LH
通讯作者：
Olsen LH
影响因子：
3.5
作者：
Milewska, Agata;Minczykowski, Andrzej;Wykretowicz, Andrzej
通讯作者：
Wykretowicz, Andrzej
影响因子：
18.2
作者：
Ikonomidis, Ignatios;Aboyans, Victor;Metra, Marco
通讯作者：
Metra, Marco
影响因子：
2.6
作者：
Acierno, Mark J.;Brown, Scott;Syme, Harriet M.
通讯作者：
Syme, Harriet M.
影响因子：
--
作者：
Chirinos, Julio A;Sweitzer, Nancy
通讯作者：
Sweitzer, Nancy