Nanoscale Zeolitic Imidazolate Framework (ZIF)-8 in Cancer Theranostics: Current Challenges and Prospects.
Nanoscale Zeolitic Imidazolate Framework (ZIF)-8 in Cancer Theranostics: Current Challenges and Prospects.
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DOI：
10.3390/cancers14163935
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发表时间：
2022-08-15
期刊：
影响因子：
5.2
通讯作者：
Gong, Yan
中科院分区：
文献类型：
--
作者：
Xie, Hongxin;Liu, Xinyu;Huang, Zhengrong;Xu, Liexi;Bai, Rui;He, Fajian;Wang, Mengqin;Han, Linzhi;Bao, Zhirong;Wu, Yuzhou;Xie, Conghua;Gong, Yan
关键词：
金属有机骨架材料在肿瘤诊断治疗中的应用已成为近年来的研究热点。ZIF-8作为其中的典型代表，由于其良好的性能和潜力，引起了越来越多的研究者的兴趣。本文综述了近年来基于ZIF-8的抗癌纳米平台的研究进展，讨论了ZIF-8在临床应用中存在的问题和障碍，并对其未来的发展提出了展望。癌症严重威胁人类健康，几十年来一直是疾病相关死亡的主要原因。随着纳米医学的迅速发展，纳米尺度的金属-有机骨架材料被认为在各种肿瘤的治疗和生物医学成像方面具有潜在的应用前景。咪唑骨架分子筛（ZIF-8）因其高孔隙率、大比表面积和pH响应性而受到越来越多的关注。ZIF-8纳米颗粒的设计和修饰以及载药策略需要对纳米材料特征和肿瘤特征有多方面和全面的了解。我们在Web of Science上检索了2015年至2022年基于ZIF-8纳米平台的肿瘤治疗诊断研究，主要集中在过去3年发表的研究，总结了其在肿瘤成像和治疗中的应用进展，并讨论了ZIF-8纳米颗粒用于肿瘤治疗诊断的有利方面以及未来的机遇和潜在的挑战。作为一种充满潜力的金属有机骨架材料，ZIF-8未来有望与更多的治疗系统相结合，继续为肿瘤治疗和诊断的各个方面做出贡献。
The biomedical application of metal–organic frameworks in cancer theranostics has become a research hotspot with rapid progress. As a typical representative, ZIF–8 attracts increasing interest from researchers due to its good performance and potential. In this review, we updated recent discoveries on the ZIF–8–based nanoplatforms for cancer, discussed the problems in current research and the obstacles for clinical translation of ZIF–8, and also proposed an outlook on its future development. Cancer severely threatens human health and has remained the leading cause of disease–related death for decades. With the rapid advancement of nanomedicine, nanoscale metal–organic frameworks are believed to be potentially applied in the treatment and biomedical imaging for various tumors. Zeolite imidazole framework (ZIF)–8 attracts increasing attention due to its high porosity, large specific surface area, and pH–responsiveness. The designs and modifications of ZIF–8 nanoparticles, as well as the strategy of drug loading, demand a multifaceted and comprehensive understanding of nanomaterial features and tumor characteristics. We searched for studies on ZIF–8–based nanoplatforms in tumor theranostics on Web of Science from 2015 to 2022, mainly focused on the research published in the past 3 years, summarized the progress of their applications in tumor imaging and treatment, and discussed the favorable aspects of ZIF–8 nanoparticles for tumor theranostics as well as the future opportunities and potential challenges. As a kind of metal–organic framework material full of potential, ZIF–8 can be expected to be combined with more therapeutic systems in the future and continue to contribute to all aspects of tumor therapy and diagnosis.
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