Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes.
Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes.
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DOI：
10.1007/s00018-014-1638-8
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发表时间：
2014-10
影响因子：
8
通讯作者：
Devreotes, Peter N.
中科院分区：
文献类型：
--
作者：
Artemenko, Yulia;Lampert, Thomas J.;Devreotes, Peter N.
趋化性，或细胞沿着化学梯度定向迁移，是一个高度协调的过程，涉及梯度感应、运动性和极性。我们对趋化性的理解大多来自于对经历变形虫型迁移的细胞的研究，特别是社会性变形虫Dictyosteelium discoideum和白细胞。在这些变形虫细胞中，导致定向迁移的分子事件可以在概念上分为四个相互作用的网络：受体/G蛋白，信号转导，细胞骨架和极性。信号转导网络在该方案中占据中心位置，因为它接收来自受体/G蛋白网络的直接输入，以及来自细胞骨架和极性网络的反馈。信号转导网络中的多个重叠模块将信号传递到肌动蛋白细胞骨架网络，导致在梯度方向上偏向伪足突出。网络的整体架构，以及个别的信号模块是显着保守的Dictyosteoblasts和哺乳动物白细胞之间，这两个系统之间的相似性和差异是本次审查的主题。
Chemotaxis, or directed migration of cells along a chemical gradient, is a highly coordinated process that involves gradient sensing, motility, and polarity. Most of our understanding of chemotaxis comes from studies of cells undergoing amoeboid-type migration, in particular the social amoeba Dictyostelium discoideum and leukocytes. In these amoeboid cells the molecular events leading to directed migration can be conceptually divided into four interacting networks: receptor/G protein, signal transduction, cytoskeleton, and polarity. The signal transduction network occupies a central position in this scheme as it receives direct input from the receptor/G protein network, as well as feedback from the cytoskeletal and polarity networks. Multiple overlapping modules within the signal transduction network transmit the signals to the actin cytoskeleton network leading to biased pseudopod protrusion in the direction of the gradient. The overall architecture of the networks, as well as the individual signaling modules are remarkably conserved between Dictyostelium and mammalian leukocytes, and the similarities and differences between the two systems are the subject of this review.
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影响因子：
11.4
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作者：
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