PAI-1, Obesity, Insulin Resistance and Risk of Cardiovascular Events
PAI-1, Obesity, Insulin Resistance and Risk of Cardiovascular Events
复制标题
PAI-1、肥胖、胰岛素抵抗和心血管事件风险
作者：
I. Juhan;M. Alessi
冠心病患者循环(PAI-1)水平升高，可能在动脉粥样硬化血栓形成中起重要作用。许多临床研究表明，胰岛素抵抗综合征可能是PAI-1表达的主要调节因子，特别是在测定血浆PAI-1水平时。中心性肥胖是胰岛素抵抗的一个特征，也是公认的冠心病危险因素。最近，脂肪组织，特别是大网膜组织产生PAI-1已被证实，这可能是胰岛素抵抗患者血浆PAI-1水平升高的重要原因。除了代谢状态对血浆PAI-1水平的影响外，基因控制的作用也被强调，但根据最近在家庭隔离研究中获得的结果，它的参与似乎是有限的。对既往有心肌梗死或心绞痛患者的前瞻性队列研究强调了血浆PAI-1水平升高与冠状动脉事件风险之间的关联，但在胰岛素抵抗标志物调整后，PAI-1的预测能力消失。综上所述，这些结果支持PAI-1可能是肥胖、胰岛素抵抗和心血管疾病之间的联系的观点。
Circulating (PAI-1) levels are elevated in patients with coronary heart disease and may play an important role in the development of atherothrombosis. Many clinical studies have indicated that the insulin resistance syndrome, which is a situation predisposing to diabetes and ischemic heart disease, may be a major regulator of PAI-1 expression, especially in determining plasma PAI-1 levels. Central obesity is a characteristic of insulin resistance and is a well recognized risk factor for coronary heart disease. Recently the production of PAI-1 by adipose tissue, in particular by tissue from omentum, has been demonstrated and could be an important contributor to the elevated plasma PAI-1 levels observed in insulin resistant patients. Besides the effect of the metabolic status on plasma PAI-1 levels, the role of a genetic control has been emphasized, but according to recent results obtained in a family segregation study, its participation seems limited. Prospective cohort studies of patients with previous myocardial infarction or angina pectoris have underlined the association between increased plasma PAI-1 levels and the risk of coronary events, but the predictive capacity of PAI-1 disappears after insulin resistance marker adjustments. Taken together these results support the notion that PAI-1 can be a link between obesity, insulin resistance and cardiovascular disease.
影响因子：
15.9
作者：
Samad, F;Yamamoto, K;Loskutoff, DJ
通讯作者：
Loskutoff, DJ
影响因子：
37.8
作者：
Lundgren, CH;Brown, SL;Fujii, S
通讯作者：
Fujii, S
DOI：
10.1161/01.atv.13.2.162
发表时间：
1993-02-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
FOLSOM, AR;QAMHIEH, HT;WU, KK
通讯作者：
WU, KK