Steroid hormone content of the gonads of the tammar wallaby during sexual differentiation.
Steroid hormone content of the gonads of the tammar wallaby during sexual differentiation.
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塔玛袋鼠性分化过程中性腺的类固醇激素含量。
DOI：
10.1095/biolreprod47.4.644
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发表时间：
1992
影响因子：
3.6
通讯作者：
George,FW
中科院分区：
文献类型：
--
作者：
Renfree,MB;Wilson,JD;Short,RV;Shaw,G;George,FW
的tammar小袋鼠，Macropus eugenii的性腺，出生时（第0天）性冷淡，尽管事实上，表型性分化已经开始，证明了存在的阴囊在男性和女性的乳房原基。睾丸的生精索在育儿袋生活的第2天首次变得清晰可辨，卵巢分化在第10天可识别。为了监测泌尿生殖道性分化过程中性腺内分泌的发育，我们测定了92个雄、雌绒袋幼鱼性腺池中从出生之日到206天的类固醇激素含量，孕酮、雌二醇和双氢睾酮浓度较低，（< 0.05纳克/毫克蛋白质），卵巢中的睾酮浓度一致较低。第0-4天，睾丸中的睾酮浓度较低，平均约为0.2 ng/mg蛋白质;第5-10天，睾酮浓度升高至平均0.9 ng/mg蛋白质，直至第40天左右仍保持升高状态，此后降至与卵巢相似的值。阴茎和尿生殖窦能够从检查的最早阶段（第10天和第11天）将睾酮转化为双氢睾酮。因此，在tammar wallaby中，与真兽目哺乳动物一样，睾酮是由发育中的睾丸分泌的雄激素，双氢睾酮在某些雄激素靶组织中形成。在男性泌尿生殖道开始男性化之前，睾丸睾酮浓度的升高和靶组织中形成dthydrotestosterone的能力都是可以证明的，这一发现表明组织最初缺乏对这些雄激素做出反应的能力。男性阴囊或女性乳腺原基的发育先于性腺类固醇浓度的可测量的增加，这一事实与阴囊和乳腺的两性异形不依赖于性腺类固醇的假设一致。
The gonads of the tammar wallaby,Macropus eugenii, are sexually indifferent at birth (Day 0) despite the fact that phenotypic sexual differentiation has already commenced as evidenced by the presence of a scrotum in males and mammary anlagen in females. The seminiferous cords of the testis first become clearly recognizable on Day 2 of pouch life, and ovarian differentiation is recognizable by Day 10. To monitor the endocrine development of the gonads during sexual differentiation of the urogenital tract, we measured the steroid hormone content in 92 pools of gonads from male and female tammar pouch young from the day of birth to 206 days of pouch life.Progesterone, estradiol, and dihydrotestosterone concentrations were low (< 0.05 ng/mg protein) in both ovaries and testes at all stages examined, and testosterone concentrations were uniformly low in ovaries. Testosterone concentrations in testes were low on Days 0–4, averaging about 0.2 ng/mg protein; they rose by Days 5–10 to an average of 0.9 ng/mg protein, remained elevated until about Day 40, and thereafter fell to values similar to those in the ovaries. The phallus and urogenital sinus were able to convert testosterone to dihydrotestosterone from the earliest stages examined (Days 10 and 11).Thus in the tammar wallaby, as in eutherian mammals, testosterone is the androgen secreted by the developing testis, and dihydrotestosterone is formed in certain androgen target tissues. The finding that both the rise in testicular testosterone concentration and the capacity to form dthydrotestosterone in target tissues are demonstrable before the male urogenital tract begins to virilize suggests that the tissues Initially lack the capacity to respond to these androgens. The fact that the development of a scrotum in the male or mammary anlagen in the female precedes a measurable increase in gonadal steroid concentrations is in keeping with the hypothesis that sexual dimorphism of the scrotum and mammary glands is not dependent on gonadal steroids.
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未成熟睾丸对塔玛袋鼠，Macropus eugenii（Macropodidae：Marsupialia）性别分化的影响。
DOI：
10.1071/rd9890243
发表时间：
1989
期刊：
Reproduction, fertility, and development
影响因子：
--
作者：
CH Tyndale;L. Hinds
通讯作者：
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影响因子：
4.6
作者：
J. Hutson;G. Shaw;W. O;R. Short;M. Renfree
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M. Renfree
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DOI：
--
发表时间：
1989
期刊：
影响因子：
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作者：
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R. Short
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影响因子：
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作者：
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DOI：
--
发表时间：
1939
期刊：
影响因子：
--
作者：
R. Burns
通讯作者：
R. Burns