Does the Cerebellum Provide a Common Computation for Diverse Tasks? A Timing Hypothesis a
Does the Cerebellum Provide a Common Computation for Diverse Tasks? A Timing Hypothesis a
复制标题
小脑是否为不同的任务提供通用的计算？
DOI：
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发表时间：
1990
影响因子：
5.2
通讯作者：
R. Ivry
中科院分区：
文献类型：
--
作者：
S. Keele;R. Ivry
小脑为许多任务提供时间计算。我们已经发现，定时运动反应的准确性在不同的运动效应器之间是相关的。此外，判断听觉间隔持续时间的感知敏锐度与定时的运动测量相关。这些结果表明，不同种类的时间背后有一个共同的过程，这个过程可能取决于一个特定的神经系统。我们的数据表明，小脑损伤损害运动和知觉的时间。小脑损伤的患者在判断移动的视觉刺激的速度方面也受到损害，这一过程似乎需要精确的时间。此外，外侧小脑已牵连在经典的“眨眼”条件反射的兔子的瞬膜反应。由于经典的条件离散，适应性反应是精确的时间，我们认为，小脑是这个反应的条件网站，因为需要时间计算。心率等反应的经典条件反射并不依赖于小脑，但时间并不那么精确。小脑对运动的影响也可能是提供时间信息。作为一个群体，笨拙的儿童不仅在运动产生方面，而且在感知方面都表现出很差的时间性，这是因为他们的一般计算能力受损。由于发现小脑在经典条件作用中的重要性，我们开始关于经典条件作用的讨论。
The cerebellum provides a temporal computation for a number of tasks. We have found that the accuracy in timing motor responses is correlated across different motor effectors. Moreover, perceptual acuity in judging durations of auditory intervals is correlated with motoric measures of timing. These results suggest a common process underlying timing of different sorts, and that this process may depend on a specific neural system. Our data indicate that damage to the cerebellum impairs motor and perceptual timing. Patients with cerebellar lesions are also impaired at judging the velocity of a moving visual stimulus, a process that would appear to require precise timing. Furthermore, the lateral cerebellum has been implicated in classical “eyeblink” conditioning of the rabbit’s nictitating membrane response. Because classical conditioning of discrete, adaptive responses is precisely timed, we argue that the cerebellum is the conditioning site for this response because of the need for temporal computation. Classical conditioning of responses such as of heart rate, which is not so precisely timed, does not depend on the cerebellum. The cerebellar influence on locomotion may also be one of providing temporal information. Clumsy children appear as a group to have poor timing, not only on motor production but on perception as well, as would be expected if a general computation is impaired. Because of the importance of the discovery of a cerebellar role in classical conditioning, we begin our argument with respect to classical conditioning.
影响因子：
56.9
作者：
POSNER, MI;PETERSEN, SE;RAICHLE, ME
通讯作者：
RAICHLE, ME
影响因子：
2.5
作者：
HORAK, FB;ANDERSON, ME
通讯作者：
ANDERSON, ME