CD56 Expression Marks Human Group 2 Innate Lymphoid Cell Divergence from a Shared NK Cell and Group 3 Innate Lymphoid Cell Developmental Pathway.
CD56 Expression Marks Human Group 2 Innate Lymphoid Cell Divergence from a Shared NK Cell and Group 3 Innate Lymphoid Cell Developmental Pathway.
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DOI：
10.1016/j.immuni.2018.08.010
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发表时间：
2018-09-18
期刊：
影响因子：
32.4
通讯作者：
Freud AG
中科院分区：
文献类型：
--
作者：
Chen L;Youssef Y;Robinson C;Ernst GF;Carson MY;Young KA;Scoville SD;Zhang X;Harris R;Sekhri P;Mansour AG;Chan WK;Nalin AP;Mao HC;Hughes T;Mace EM;Pan Y;Rustagi N;Chatterjee SS;Gunaratne PH;Behbehani GK;Mundy-Bosse BL;Caligiuri MA;Freud AG
根据已建立的小鼠先天淋巴细胞（ILC）发育模型，辅助ILC与自然杀伤（NK）细胞分开发育。然而，目前还不清楚辅助ILC和NK细胞如何在人类中发育。在这里，我们阐明了NK细胞，ILC2和ILC3的发展在人类扁桃体内使用离体分子和功能分析和谱系分化测定的关键步骤。我们证明，虽然扁桃体NK细胞，ILC2和ILC3起源于共同的CD34−CD117+ ILC前体库，但ILC2发育的最终步骤独立偏离，并与NK细胞和ILC3的发育途径相互排斥。此外，我们鉴定了一个表达CD56的CD34−CD117+ ILC前体群体，并产生NK细胞和ILC3，但不产生ILC2。这些数据支持与小鼠不同的人ILC发育模型，其中人NK细胞和ILC3共享与ILC2分开的共同发育途径。人类先天性淋巴样细胞（ILC）是由次级淋巴样组织中的组织驻留ILC前体（ILCP）发育而来。在这里，Chen及其同事描述了一种扁桃体中人类ILC发育的模型，其中NK细胞和第3组ILC来源于不能分化为第2组ILC的ILCP的CD56+亚群。
According to the established model of murine innate lymphoid cell (ILC) development, helper ILCs develop separately from natural killer (NK) cells. However, it is unclear how helper ILCs and NK cells develop in humans. Here we elucidated key steps of NK cell, ILC2, and ILC3 development within human tonsils using ex vivo molecular and functional profiling and lineage differentiation assays. We demonstrated that while tonsillar NK cells, ILC2s, and ILC3s originated from a common CD34−CD117+ ILC precursor pool, final steps of ILC2 development deviated independently and became mutually exclusive from those of NK cells and ILC3s, whose developmental pathways overlapped. Moreover, we identified a CD34−CD117+ ILC precursor population that expressed CD56 and gave rise to NK cells and ILC3s but not to ILC2s. These data support a model of human ILC development distinct from the mouse, whereby human NK cells and ILC3s share a common developmental pathway separate from ILC2s. Human innate lymphoid cells (ILCs) develop from tissue-resident ILC precursors (ILCPs) in secondary lymphoid tissues. Here, Chen and colleagues describe a model of human ILC development in tonsils in which NK cells and group 3 ILCs derive from a CD56+ subset of ILCPs that cannot differentiate into group 2 ILCs.
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影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
影响因子：
17.1
作者：
Horowitz A;Strauss-Albee DM;Leipold M;Kubo J;Nemat-Gorgani N;Dogan OC;Dekker CL;Mackey S;Maecker H;Swan GE;Davis MM;Norman PJ;Guethlein LA;Desai M;Parham P;Blish CA
通讯作者：
Blish CA
影响因子：
32.4
作者：
Bernink, Jochem H.;Krabbendam, Lisette;Spits, Hergen
通讯作者：
Spits, Hergen
DOI：
10.1126/science.1198704
发表时间：
2011-05-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bendall SC;Simonds EF;Qiu P;Amir el-AD;Krutzik PO;Finck R;Bruggner RV;Melamed R;Trejo A;Ornatsky OI;Balderas RS;Plevritis SK;Sachs K;Pe'er D;Tanner SD;Nolan GP
通讯作者：
Nolan GP
影响因子：
30.5
作者：
Bernink, Jochem H.;Peters, Charlotte P.;Spits, Hergen
通讯作者：
Spits, Hergen