The effect of acute oral erythromycin on gallbladder motility and on upper gastrointestinal symptoms in gastrectomized patients with and without gallstones: a randomized, placebo-controlled ultrasonographic study
The effect of acute oral erythromycin on gallbladder motility and on upper gastrointestinal symptoms in gastrectomized patients with and without gallstones: a randomized, placebo-controlled ultrasonographic study
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急性口服红霉素对伴或不伴胆结石的胃切除患者胆囊运动和上消化道症状的影响：一项随机、安慰剂对照超声研究
DOI：
10.1111/j.1572-0241.2000.03282.x
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发表时间：
2000
影响因子：
9.8
通讯作者：
G. Palasciano
中科院分区：
文献类型：
--
作者：
P. Portincasa;D. Altomare;A. Moschetta;G. Baldassarre;A. Ciaula;N. Venneman;M. Rinaldi;G. Vendemiale;V. Memeo;G. P. vanBerge;G. Palasciano
目的：胃切除术可能是胆石症的危险因素，胆囊郁积可能起主要作用。我们研究了空腹和餐后胆囊运动与600毫克口服红霉素或安慰剂在gastrectomized患者（有和无胆结石）和controls.METHODS：17例胃癌手术（胃大部切除术：n = 10，全胃切除术：n = 7）进行了比较，与20个性别和身体大小匹配的健康对照。受试者在摄入标准的200 ml液体试验餐前30分钟随机接受红霉素或安慰剂。通过超声检查估计胆囊体积，直至试验餐后120分钟。视觉模拟量表监测胃肠道对食欲、饱腹感、恶心、腹胀和上腹痛的感知。结果：胃切除术患者的空腹胆囊体积（35.9 ± 3.4 ml vs 21.0 ± 1.4 ml，p= 0.0005）比对照组增加，餐后排空（T/2 14.8 ± 1.1 min vs 23.5 ± 1.5 min，p= 0.00019）更快。6例患者出现小而无症状的胆囊结石，但不影响胆囊运动。在这些患者中，术后空腹胆囊体积随时间增加（r =+ 0.82，p= 0.047）。进食试验餐后，患者的饱腹感、腹胀感和上腹痛感均显著高于对照组。红霉素显著增强患者和对照组空腹（p= 0.001）和餐后（0.002< p < 0.017）的胆囊排空，显著降低胃切除患者的餐后饱腹感和上腹部不适。红霉素改善空腹和餐后胆囊排空，并减少胃切除患者的上消化道症状。
OBJECTIVE:Gastrectomy might be a risk factor for cholelithiasis and gallbladder stasis might play a major role. We studied fasting and postprandial gallbladder motility with 600 mg oral erythromycin or placebo in gastrectomized patients (with and without gallstones) and controls.METHODS:Seventeen patients operated on for gastric cancer (subtotal gastrectomy: n = 10, total gastrectomy: n = 7) were compared with 20 sex- and body-size matched healthy controls. Subjects randomly received erythromycin or placebo 30 min before the ingestion of a standard 200 ml liquid test meal. Gallbladder volume was estimated by ultrasonography until 120 min after test meal. A visual analog scale monitored GI perception of appetite, satiety, nausea, abdominal fullness and epigastric pain.RESULTS:Gastrectomized patients had increased fasting gallbladder volume (35.9 ± 3.4 ml versus 21.0 ± 1.4 ml, p= 0.0005) with faster postmeal emptying (T/2 14.8 ± 1.1 min versus 23.5 ± 1.5 min, p= 0.00019) than controls. Six patients developed small and asymptomatic gallstones, which did not influence gallbladder motility. In these patients, fasting gallbladder volume increased with time after surgery (r =+ 0.82, p= 0.047). Perception of satiety, abdominal fullness, and epigastric pain after ingestion of the test meal were all significantly greater in patients than in controls. Erythromycin significantly enhanced gallbladder emptying during fasting (p= 0.001) and postprandially in both patients and controls (0.002< p < 0.017) and significantly reduced postmeal satiety and epigastric discomfort in gastrectomized patients.CONCLUSIONS:Increased fasting volume might be a form of stasis, predisposing patients to gallstone formation. Erythromycin improves fasting and postprandial gallbladder emptying and decreases upper GI symptoms in gastrectomized patients.
镰状血红蛋白病的胆囊功能发生改变。
影响因子：
29.4
作者：
Everson,GT;Nemeth,A;Kourourian,S;Zogg,D;Leff,NB;Dixon,D;Githens,JH;Pretorius,D
通讯作者：
Pretorius,D
胆碱能对人类胆囊排空的影响。
影响因子：
29.4
作者：
Fisher,RS;Rock,E;Malmud,LS
通讯作者：
Malmud,LS