Association between smoking and latent tuberculosis in the U.S. population: an analysis of the National Health and Nutrition Examination Survey.
Association between smoking and latent tuberculosis in the U.S. population: an analysis of the National Health and Nutrition Examination Survey.
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DOI：
10.1371/journal.pone.0049050
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Narita M
中科院分区：
文献类型：
--
作者：
Horne DJ;Campo M;Ortiz JR;Oren E;Arentz M;Crothers K;Narita M
吸烟与潜伏性结核感染（LTBI）之间相关性的证据是基于对特殊人群和/或高患病率环境的研究。我们试图使用来自国家健康和营养调查（NHANES）的基于人群的数据来评估低患病率结核病背景下LTBI和吸烟之间的关联。在1999-2000年，NHANES评估了参与者的LTBI（定义为结核菌素皮肤试验测量≥10 mm），并询问了≥20岁的参与者的烟草使用情况，并测量了血清可替宁。我们在多变量logistic回归模型中评估了LTBI与自我报告的吸烟史和吸烟强度的相关性，该模型调整了已知的混杂因素（性别、年龄、出生地、种族/民族、贫困、教育、BCG疫苗接种史和家庭结核病暴露史）。在≥20岁的患者中，估计的LTBI患病率为5.3%。不吸烟者、当前吸烟者和既往吸烟者的LTBI患病率分别为4.1%、6.6%和6.2%。在多变量模型中，当前吸烟与LTBI相关（OR 1.8; 95%CI，1.1-2.9）。吸烟与LTBI之间的关联在墨西哥裔美国人和黑人中最强。在按种族/民族分层的多变量分析中，墨西哥裔美国人吸烟者每天的香烟盒数和黑人吸烟者的可替宁水平与LTBI显著相关。在大的，有代表性的，基于人群的NHANES样本中，吸烟与LTBI风险显著增加独立相关。在某些人群中，LTBI的风险增加与吸烟暴露增加相对应。
Evidence of an association between cigarette smoking and latent tuberculosis infection (LTBI) is based on studies in special populations and/or from high prevalence settings. We sought to evaluate the association between LTBI and smoking in a low prevalence TB setting using population-based data from the National Health and Nutrition Examination Survey (NHANES). In 1999–2000, NHANES assessed LTBI (defined as a tuberculin skin test measurement ≥10 mm) in participants, and those ≥20 years of age were queried regarding their tobacco use and serum cotinine was measured. We evaluated the association of LTBI with self-reported smoking history and smoking intensity in multivariable logistic regression models that adjusted for known confounders (gender, age, birthplace, race/ethnicity, poverty, education, history of BCG vaccination, and history of household exposure to tuberculosis disease). Estimated LTBI prevalence was 5.3% among those ≥20 years of age. The LTBI prevalence among never smokers, current smokers, and former smokers was 4.1%, 6.6%, and 6.2%, respectively. In a multivariable model, current smoking was associated with LTBI (OR 1.8; 95% CI, 1.1–2.9). The association between smoking and LTBI was strongest for Mexican-American and black individuals. In multivariate analysis stratified by race/ethnicity, cigarette packs per day among Mexican-American smokers and cotinine levels among black smokers, were significantly associated with LTBI. In the large, representative, population-based NHANES sample, smoking was independently associated with significantly increased risks of LTBI. In certain populations, a greater risk of LTBI corresponded with increased smoking exposure.
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DOI：
10.1164/rccm.200706-950oc
发表时间：
2008-02-15
影响因子：
24.7
作者：
Khan, Kamran;Wang, Jun;Gardam, Michael
通讯作者：
Gardam, Michael
影响因子：
7.7
作者：
Hussain, H;Akhtar, S;Nanan, D
通讯作者：
Nanan, D
影响因子：
9.4
作者：
Singh, Pushpendra;Wesley, Clement;Katoch, V. A.
通讯作者：
Katoch, V. A.
影响因子：
120.7
作者：
Pérez-Stable, EJ;Herrera, B;Benowitz, NL
通讯作者：
Benowitz, NL
影响因子：
2.3
作者：
Brick, J M;Kalton, G
通讯作者：
Kalton, G