hermaphrodite and doublesex function both dependently and independently to control various aspects of sexual differentiation in Drosophila.
hermaphrodite and doublesex function both dependently and independently to control various aspects of sexual differentiation in Drosophila.
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雌雄同体和双性功能既依赖又独立地控制果蝇性别分化的各个方面。
作者：
Hao Li;Bruce S. Baker
雌雄同体（her）基因是果蝇性别分化所必需的。我们对她的合子功能的表征表明，一组雌性特异性的末端分化基因，卵黄蛋白（yp）基因，通过两个不同的途径转录激活。一条是雌性特异性途径，由雌性特异性双性蛋白（DSXF）正调控。另一种是非性别特异性的途径，由HER积极调节。男性特异性双性蛋白（DSXM）的作用阻止了HER途径在男性中的功能。HER和DSX通路也独立地控制前体细胞中的下游靶基因，这些前体细胞产生雌性阴道齿和雄性背肛板，以及雄性侧肛板。然而，依赖于DSXF和HER的雌性特异性通路控制着前腿刚毛和5、6号肌体的雌性特异性分化，而这些组织的雄性特异性分化不需要DSXM抑制HER的功能。
The hermaphrodite (her) gene is necessary for sexual differentiation in Drosophila. Our characterization of her's zygotic function suggests that one set of female-specific terminal differentiation genes, the yolk protein (yp) genes, is transcriptionally activated by two separate pathways. One is a female-specific pathway, which is positively regulated by the female-specific doublesex protein (DSXF). The other is a non-sex-specific pathway, that is positively regulated by HER. The HER pathway is prevented from functioning in males by the action of the male-specific doublesex protein (DSXM). The HER and DSX pathways also function independently to control downstream target genes in the precursor cells that give rise to the vaginal teeth and dorsal anal plate of females, and the lateral anal plates of males. However, a female-specific pathway that is dependent on both DSXF and HER controls the female-specific differentiation of the foreleg bristles and tergites 5 and 6, and the male-specific differentiation of these tissues does not require the suppression of HER's function by DSXM.
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果蝇腹部神经母细胞对雄性或雌性命运的承诺取决于性别决定等级的基因。
DOI：
10.1242/dev.114.3.625
发表时间：
1992
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Taylor,BJ;Truman,JW
通讯作者：
Truman,JW
无脊椎动物的性别决定和分化：果蝇和秀丽隐杆线虫。
影响因子：
7.5
作者：
McKeown,M;Madigan,SJ
通讯作者：
Madigan,SJ
影响因子：
10.5
作者：
COSCHIGANO, KT;WENSINK, PC
通讯作者：
WENSINK, PC
无结果基因座的元素调节劳伦斯肌肉的发育，劳伦斯肌肉是果蝇成虫腹部的雄性特异性结构。
DOI：
10.1242/dev.113.3.879
发表时间：
1991
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Gailey,DA;Taylor,BJ;Hall,JC
通讯作者：
Hall,JC
影响因子：
3.3
作者：
Villella,A;Hall,JC
通讯作者：
Hall,JC