NCAM regulates temporal specification of neural progenitor cells via profilin2 during corticogenesis

NCAM regulates temporal specification of neural progenitor cells via profilin2 during corticogenesis
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NCAM 在皮质生成过程中通过 profilin2 调节神经祖细胞的时间规范

DOI:
10.1083/jcb.201902164
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发表时间:
2019-12
影响因子:
7.8
通讯作者:
Li Shen
Li Shen
中科院分区:
生物学1区
文献类型:
--
作者:
Huang Rui;Yuan De Juan;Li Shao;Liang Xue Song;Gao Yue;Lan Xiao Yan;Qin Hua Min;Ma Yu Fang;Xu Guang Yin;Schachner Melitta;Sytnyk Vladimir;Boltze Johannes;Ma Quan Hong;Li Shen

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NCAM在皮质发生中的作用尚不完全清楚。作者证明NCAM通过依赖于profin2的肌动蛋白聚合调控NPC的增殖和命运决定。这一发现为NCAM的功能提供了新的线索
The role of NCAM in corticogenesis is incompletely understood. The authors demonstrate that NCAM controls NPC proliferation and fate decision through profilin2-dependent regulation of actin polymerization. This finding sheds new light on NCAM’s functions
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