Specialised ribosomes as versatile regulators of gene expression.

Specialised ribosomes as versatile regulators of gene expression.
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DOI:
10.1080/15476286.2022.2135299
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发表时间:
2022-01
期刊:
影响因子:
4.1
通讯作者:
Shin, Eunkyoung
Shin, Eunkyoung
中科院分区:
生物学3区
文献类型:
--
作者:
Joo, Minju;Yeom, Ji-Hyun;Choi, Younkyung;Jun, Hyeon;Song, Wooseok;Kim, Hyun-Lee;Lee, Kangseok;Shin, Eunkyoung

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The ribosome has long been thought to be a homogeneous cellular machine that constitutively and globally synthesises proteins from mRNA. However, recent studies have revealed that ribosomes are highly heterogeneous, dynamic macromolecular complexes with specialised roles in translational regulation in many organisms across the kingdoms. In this review, we summarise the current understanding of ribosome heterogeneity and the specialised functions of heterogeneous ribosomes. We also discuss specialised translation systems that utilise orthogonal ribosomes.
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