Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention.
Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention.
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DOI：
10.1126/science.abb9601
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发表时间：
2020-07-03
期刊：
影响因子：
--
通讯作者：
Papadopoulos N
中科院分区：
文献类型：
--
作者：
Lennon AM;Buchanan AH;Kinde I;Warren A;Honushefsky A;Cohain AT;Ledbetter DH;Sanfilippo F;Sheridan K;Rosica D;Adonizio CS;Hwang HJ;Lahouel K;Cohen JD;Douville C;Patel AA;Hagmann LN;Rolston DD;Malani N;Zhou S;Bettegowda C;Diehl DL;Urban B;Still CD;Kann L;Woods JI;Salvati ZM;Vadakara J;Leeming R;Bhattacharya P;Walter C;Parker A;Lengauer C;Klein A;Tomasetti C;Fishman EK;Hruban RH;Kinzler KW;Vogelstein B;Papadopoulos N
癌症治疗通常在疾病早期发现时更成功。我们评估了多癌症血液检测结合PET-CT成像的可行性和安全性，以在一项前瞻性干预性研究中检测癌症，该研究涉及10，006名先前未知患有癌症的女性。阳性血液检查由诊断性PET-CT独立证实，该诊断性PET-CT也定位了癌症。通过血液检测发现了26种癌症。其中，15例接受了PET-CT成像，9例（60%）手术切除。另外24例癌症通过标准护理筛查检测到，46例通过两种方法都没有检测到。1.0%的参与者接受了基于假阳性血液检查的PET-CT成像，0.22%的参与者接受了无效的侵入性诊断程序。这些数据表明，多癌症血液检测与PET-CT相结合可以安全地纳入常规临床护理，在某些情况下导致手术治疗。
Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multi-cancer blood testing coupled with PET-CT imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnostic PET-CT, which also localized the cancer. Twenty-six cancers were detected by blood testing. Of these, 15 underwent PET-CT imaging and nine (60%) were surgically excised. Twenty-four additional cancers were detected by standard-of-care screening and 46 by neither approach. 1.0% of participants underwent PET-CT imaging based on false positive blood tests, and 0.22% underwent a futile invasive diagnostic procedure. These data demonstrate that multi-cancer blood testing combined with PET-CT can be safely incorporated into routine clinical care, in some cases leading to surgery with intent to cure.
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DOI：
10.1073/pnas.0507904102
发表时间：
2005-11-08
影响因子：
11.1
作者：
Diehl, F;Li, M;Vogelstein, B
通讯作者：
Vogelstein, B
影响因子：
5.5
作者：
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Breen, Nancy
影响因子：
3.6
作者：
Brehaut, JC;O'Connor, AM;Feldman-Stewart, D
通讯作者：
Feldman-Stewart, D
DOI：
10.1038/s41571-018-0002-6
发表时间：
2018-06
期刊：
Nature reviews. Clinical oncology
影响因子：
--
作者：
Berger MF;Mardis ER
通讯作者：
Mardis ER
影响因子：
7.9
作者：
Ahlquist, David A.
通讯作者：
Ahlquist, David A.