Elevated stearoyl-CoA desaturase 1 activity is associated with alcohol-associated liver disease.
Elevated stearoyl-CoA desaturase 1 activity is associated with alcohol-associated liver disease.
复制标题
DOI：
10.1016/j.alcohol.2022.04.001
复制
发表时间：
2022-08
期刊：
影响因子：
2.3
通讯作者：
Ramchandani, V. A.
中科院分区：
文献类型：
--
作者：
Klepp, T. D.;Sloan, M. E.;Soundararajan, Soundarya;Ramsden, C. E.;Cinar, R.;Schwandt, M. L.;Diazgranados, N.;Vatsalya, V.;Ramchandani, V. A.
关键词：
慢性酗酒会导致肝脏脂质堆积，但只有某些个体才会患上酒精相关性肝病（ALD）。特定的脂质堆积模式被认为与ALD相关，但到目前为止尚未进行全面研究。我们分析了通过气相色谱 - 质谱法对一组酒精使用障碍（AUD）患者样本所测定的血浆脂肪酸水平。鉴于血清丙氨酸氨基转移酶（ALT）水平升高与ALD密切相关，根据ALT水平将患者分为两组：ALD组（ALT > 40 IU/L）和非ALD组（ALT ≤ 40 IU/L）。与非ALD组相比，ALD组的单不饱和脂肪酸浓度有升高趋势。然后将ALD组的硬脂酰辅酶A去饱和酶（SCD1）活性估计为棕榈油酸（16:1）与棕榈酸（16:0）的比值。ALD组的SCD1活性高于非ALD组。一系列线性回归模型表明，SCD1活性介导了酗酒与ALD之间的关联。这些发现提供了初步证据，表明SCD1活性可能与ALD相关。如果前瞻性验证成立，升高的SCD1活性有可能被用作一种生物标志物，以识别患ALD高风险的个体。
Chronic binge drinking induces hepatic lipid accumulation, but only certain individuals develop alcohol-associated liver disease (ALD). Specific patterns of lipid accumulation are thought to be associated with ALD, but this has not been comprehensively investigated to date. We analyzed plasma fatty acid levels quantified by gas chromatography-mass spectrometry in a sample of patients with alcohol use disorder (AUD). Given that elevation in serum alanine aminotransferase (ALT) levels are strongly associated with ALD, patients were stratified into two groups based on ALT levels: an ALD group (ALT > 40 IU/L) and a non-ALD group (ALT ≤ 40 IU/L). There was a shift towards greater concentrations of monounsaturated fatty acids in the ALD group compared to the non-ALD group. Steroyl-CoA desaturase (SCD1) activity in the ALD group was then estimated as the ratio of palmitoleic acid (16:1) to palmitic acid (16:0). SCD1 activity was greater in the ALD than the non-ALD group. A series of linear regression models demonstrated that SCD1 activity mediated the association between binge drinking and ALD. These findings provide initial evidence that SCD1 activity may be associated with ALD. If validated prospectively, elevated SCD1 activity could potentially be used as a biomarker to identify individuals at high risk for developing ALD.
登录
查看更多内容
影响因子：
64.5
作者：
Cao H;Gerhold K;Mayers JR;Wiest MM;Watkins SM;Hotamisligil GS
通讯作者：
Hotamisligil GS
影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1186/2049-9256-1-13
发表时间：
2013
期刊：
Journal of molecular psychiatry
影响因子：
--
作者：
Teubert A;Thome J;Büttner A;Richter J;Irmisch G
通讯作者：
Irmisch G
影响因子：
4.2
作者：
Miyazaki, M;Man, WC;Ntambi, JM
通讯作者：
Ntambi, JM
影响因子：
7.1
作者：
Lee, Joseph J.;Lambert, Jennifer E.;Parks, Elizabeth J.
通讯作者：
Parks, Elizabeth J.