Comparison of disease-specific survival in the United States and Korea after resection for early-stage node-negative gastric carcinoma.
Comparison of disease-specific survival in the United States and Korea after resection for early-stage node-negative gastric carcinoma.
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DOI：
10.1002/jso.23288
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发表时间：
2013-05
影响因子：
2.5
通讯作者：
Brennan MF
中科院分区：
文献类型：
--
作者：
Strong VE;Song KY;Park CH;Jacks LM;Gonen M;Shah MA;Coit DG;Brennan MF
GC患者的疾病特异性生存期（DSS）在东方和西方国家不同。目的是比较美国和韩国患者切除早期淋巴结阴性胃癌（GC）后的结局。所有患者（1995-2005年）T1 N 0胃癌，不包括胃食管肿瘤，进行了评价。通过调整国际验证的GC诺模图中的预后变量来比较DSS。该队列包括598例韩国患者和159例美国患者。美国患者的年龄和BMI显著较高。肿瘤远端位置在韩国（60% vs. 52%）和近端位置在美国（19% vs. 5%，P < 0.0001）更常见。韩国和美国之间的五年DSS没有显着差异。多变量分析后，韩国患者的DSS持续存在，与美国患者相比无显著差异（HR = 1.2，95% CI：0.3-5.2，P = 0.83）。尽管人们普遍认为东西方的胃癌不同，但当我们比较分期相似、淋巴结阴性的胃癌患者时，韩国和美国的生存率没有显著差异。这表明GC是一种异质性疾病，当比较相似的胃癌亚型时，这些差异消失了。这项研究表明，美国和韩国胃癌患者之间的相似性比以前假设的更多。
Disease-specific survival (DSS) for GC patients differs in Eastern and Western countries. The aim is to compare outcomes of US and Korean patients following resection of early-stage, node-negative gastric carcinoma (GC). All patients (1995–2005) with T1N0 gastric carcinoma, excluding gastroesophageal tumors, were evaluated. DSS was compared by adjusting for prognostic variables from an internationally validated GC nomogram. The cohort included 598 Korean patients and 159 US patients. Age and BMI were significantly higher in US patients. Distal tumor location was more frequent in Korea (60% vs. 52%) and proximal location in the US (19% vs. 5%, P < 0.0001). Five-year DSS did not differ significantly between Korea and the US. After multivariate analysis, DSS of Korean patients persisted, with no significant differences when compared to US patients (HR = 1.2, 95% CI: 0.3–5.2, P = 0.83). Despite widespread speculations that GC differs in the East and West, when we compare similarly staged, node-negative GC patients, survival did not differ significantly between Korea and the US. This suggests that GC is a heterogeneous disease and when similar subtypes of gastric cancer are compared, these differences disappear. This study suggests more similarities than previously hypothesized between US and Korean GC patients.
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影响因子：
50.5
作者：
Kim, J.;Sun, C. -L.;Ellenhorn, J. D. I.
通讯作者：
Ellenhorn, J. D. I.
影响因子：
2.6
作者：
BONENKAMP, JJ;VANDEVELDE, CJH;MARUYAMA, K
通讯作者：
MARUYAMA, K
影响因子：
2.6
作者：
RODER, JD;BONENKAMP, JJ;STEIN, HJ
通讯作者：
STEIN, HJ
DOI：
10.1053/ejso.2001.1234
发表时间：
2002-04-01
期刊：
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
影响因子：
--
作者：
Schwarz, RE;Zagala-Nevarez, K
通讯作者：
Zagala-Nevarez, K
影响因子：
2.3
作者：
Koc, Mahmut;Dizen, Hayrettin;Tez, Mesut
通讯作者：
Tez, Mesut