Associations of Circulating microRNA-221 and 222 With the Severity of Coronary Artery Lesions in Acute Coronary Syndrome Patients
Associations of Circulating microRNA-221 and 222 With the Severity of Coronary Artery Lesions in Acute Coronary Syndrome Patients
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循环 microRNA-221 和 222 与急性冠状动脉综合征患者冠状动脉病变严重程度的关系
DOI：
10.1177/00033197211034286
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发表时间：
2021-07
期刊：
影响因子：
2.8
通讯作者：
Zhi-hao Wang
中科院分区：
文献类型：
--
作者：
Xin Yu;Jian-feng Xu;Ming Song;Lei Zhang;Yi-hui Li;Lu Han;Meng-xiong Tang;Wei Zhang;Ming Zhong;Zhi-hao Wang
冠状动脉疾病（CAD）患者中microRNA-221和222（miR-221/222）的循环水平升高，但急性冠状动脉综合征（ACS）患者中循环miR-221/222与冠状动脉病变严重程度之间的关系仍不清楚。在这项研究中，通过实时荧光定量聚合酶链反应（RT-qPCR）比较了ACS患者（n = 267）和对照组（n = 71）循环miR-221/222的相对表达水平。ACS组又分为不稳定型心绞痛（UA）组（n = 191）和急性心肌梗死（AMI）组（n = 76）。在ACS中观察到循环miR-221/222的显著上调。证明了循环miR-221/222与Gensini评分之间的正线性相关性。循环miR-221/222诊断冠状动脉狭窄≥50%的曲线下面积（AUC）分别为0.605和0.643。ACS患者外周血miRNA-221/222表达水平升高，且与冠状动脉病变程度呈正相关。循环miR-221/222可能是诊断冠状动脉狭窄≥50%和ACS发生的新生物标志物。
Circulating levels of microRNA-221 and 222 (miR-221/222) in patients with coronary artery disease (CAD) are elevated, yet the relationship between circulating miR-221/222 and the severity of coronary lesions in patients with acute coronary syndrome (ACS) remains unknown. In this study, the relative expression levels of circulating miR-221/222 in patients with ACS (n = 267) and controls (n = 71) were compared by real-time fluorescence quantitative-polymerase chain reaction (RT-qPCR). The ACS group was further divided into unstable angina pectoris (UA) group (n = 191) and acute myocardial infarction (AMI) group (n = 76). Significant upregulation of circulating miR-221/222 was observed in ACS. A positive linear correlation between circulating miR-221/222 and Gensini scores was demonstrated. The area under the curve (AUC) of circulating miR-221/222 in the diagnosis of coronary artery stenosis ≥50% was 0.605 and 0.643, respectively. The circulating miRNA-221/222 expression levels in ACS patients were elevated and positively associated with the severity of the coronary artery lesions. Circulating miR-221/222 may be novel biomarkers for the diagnosis of coronary artery stenosis ≥50% and the occurrence of ACS.
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影响因子：
3.6
作者：
Mackenzie, N. C. W.;Staines, K. A.;Zhu, D.;Genever, P.;MacRae, V. E.
通讯作者：
MacRae, V. E.
影响因子：
3.4
作者：
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作者：
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DOI：
10.1111/j.1365-2362.2009.02110.x
发表时间：
2009-05-01
影响因子：
5.5
作者：
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通讯作者：
Nakamura, M.
影响因子：
4.8
作者：
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通讯作者：
Hata, Akiko