Role of specific microRNAs in regulation of vascular smooth muscle cell differentiation and the response to injury.
Role of specific microRNAs in regulation of vascular smooth muscle cell differentiation and the response to injury.
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DOI：
10.1007/s12265-010-9163-0
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发表时间：
2010-06
影响因子：
3.4
通讯作者：
Li, Guohong
中科院分区：
文献类型：
--
作者：
Song, Zifang;Li, Guohong
血管平滑肌细胞（VSMCs）在出生后发育过程中表现出显著的可塑性。血管损伤启动并延续VSMCs去分化为合成表型，这在血管增殖性疾病的发病过程中在内膜增生中起着核心作用。MicroRNAs （miRNAs）是一类新型的调节性非编码rna，通过结合靶mrna的3 '非翻译区，在转录后水平调控基因表达，导致mrna降解或抑制其翻译。越来越多的证据表明，mirna是广泛的细胞功能（如分化、增殖和迁移）的关键调节因子。最近的研究表明，一些特定的mirna在血管细胞功能的调节中发挥重要作用，并参与血管损伤后的新生内膜增生。本文综述了近年来关于特定mirna在血管中的功能的研究进展，并讨论了mirna调节VSMCs增殖和分化的可能机制。
Vascular smooth muscle cells (VSMCs) exhibit remarkable plasticity during postnatal development. Vascular injury initiates and perpetuates VSMCs dedifferentiation to a synthetic phenotype, which has been increasingly recognized to play a central role in neointimal hyperplasia during the pathogenesis of vascular proliferative diseases. MicroRNAs (miRNAs) are a novel class of regulatory noncoding RNAs that regulate gene expression at the posttranscriptional level by binding to 3′ untranslated regions of target mRNAs, leading to either degrading mRNAs or inhibiting their translation. There is emerging evidence that miRNAs are critical regulators of widespread cellular functions such as differentiation, proliferation, and migration. Recent studies have indicated that a number of specific miRNAs play important roles in regulation of vascular cell functions and contribute to neointimal hyperplasia after vascular injury. Here, we review recent advance regarding functions of specific miRNAs in vasculature and discuss possible mechanisms by which miRNAs modulate proliferation and differentiation of VSMCs.
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影响因子：
64.8
作者：
Cordes KR;Sheehy NT;White MP;Berry EC;Morton SU;Muth AN;Lee TH;Miano JM;Ivey KN;Srivastava D
通讯作者：
Srivastava D
DOI：
10.1073/pnas.1233635100
发表时间：
2003-08-05
影响因子：
11.1
作者：
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通讯作者：
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64.5
作者：
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通讯作者：
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影响因子：
4.8
作者：
Davis, Brandi N.;Hilyard, Aaron C.;Hata, Akiko
通讯作者：
Hata, Akiko