Hippocampal interictal spikes disrupt cognition in rats.
Hippocampal interictal spikes disrupt cognition in rats.
复制标题
DOI：
10.1002/ana.21896
复制
发表时间：
2010-02
影响因子：
11.2
通讯作者：
Lenck-Santini, Pierre Pascal
中科院分区：
文献类型：
--
作者：
Kleen, Jonathan K.;Scott, Rod C.;Holmes, Gregory L.;Lenck-Santini, Pierre Pascal
Cognitive impairment is common in epilepsy, particularly in memory function. Interictal spikes are thought to disrupt cognition, but it is difficult to delineate their contribution from general impairments in memory produced by etiology and seizures. We investigated the transient impact of focal interictal spikes on the hippocampus, a structure crucial for learning and memory and yet highly prone to interictal spikes in temporal lobe epilepsy. Bilateral hippocampal depth electrodes were implanted into fourteen Sprague-Dawley rats, followed by intrahippocampal pilocarpine or saline infusion unilaterally. Rats that developed chronic spikes were trained in a hippocampal-dependent operant behavior task, delayed-match-to-sample. Depth EEG was recorded during 5,562 trials among five rats, and within-subject analyses evaluated the impact of hippocampal spikes on short-term memory operations. Hippocampal spikes that occurred during memory retrieval strongly impaired performance (p<0.001). However, spikes that occurred during memory encoding or memory maintenance did not affect performance in those trials. Hippocampal spikes also affected response latency, adding approximately 0.48 seconds to the time taken to respond (p<0.001). We found that focal interictal spike-related interference in cognition extends to structures in the limbic system, which required intrahippocampal recordings. Hippocampal spikes seem most harmful if they occur when hippocampal function is critical, extending human studies showing that cortical spikes are most disruptive during active cortical functioning. The cumulative effects of spikes could therefore impact general cognitive functioning. These results strengthen the argument that suppression of interictal spikes may improve memory and cognitive performance in patients with epilepsy.
登录
查看更多内容
影响因子：
2.9
作者：
BUZSAKI, G
通讯作者：
BUZSAKI, G
影响因子：
--
作者：
BARRY, E;SUSSMAN, NM;HARNER, RN
通讯作者：
HARNER, RN
影响因子：
3.2
作者：
Daniel, J. M.
通讯作者：
Daniel, J. M.
影响因子：
--
作者：
Hermann, BP;Seidenberg, M;Davies, K
通讯作者：
Davies, K
影响因子：
5.6
作者：
Cheung, Mei-chun;Chan, Agnes S.;Lam, Wan
通讯作者：
Lam, Wan