Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism.
Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism.
复制标题
DOI：
10.4093/dmj.2017.41.5.327
复制
发表时间：
2017-10
影响因子：
5.9
通讯作者：
Reis FCG
中科院分区：
文献类型：
--
作者：
Periasamy M;Herrera JL;Reis FCG
肥胖和糖尿病已成为地球仪的主要流行病。控制肥胖一直是一个挑战，因为这需要增加体力活动或减少热量摄入;两者都很难实施。人们重新关注利用诸如解偶联蛋白1（UCP 1）介导的棕色脂肪组织（BAT）和白色脂肪组织中的解偶联的途径来增加能量消耗以控制体重增加。然而，仅仅依靠基于UCP 1的产热可能不足以控制人类的肥胖。另一方面，骨骼肌是最大的器官，并且是基础代谢率的主要贡献者，并且通过非颤抖性产热机制增加肌肉中的能量消耗，这可以显著影响全身代谢和体重增加。在这篇综述中，我们将描述的作用Sarcolipin介导的解偶联肌浆网钙ATP酶（SERCA）作为一个潜在的机制，增加能量消耗在寒冷和饮食诱导的产热。
Obesity and diabetes has become a major epidemic across the globe. Controlling obesity has been a challenge since this would require either increased physical activity or reduced caloric intake; both are difficult to enforce. There has been renewed interest in exploiting pathways such as uncoupling protein 1 (UCP1)-mediated uncoupling in brown adipose tissue (BAT) and white adipose tissue to increase energy expenditure to control weight gain. However, relying on UCP1-based thermogenesis alone may not be sufficient to control obesity in humans. On the other hand, skeletal muscle is the largest organ and a major contributor to basal metabolic rate and increasing energy expenditure in muscle through nonshivering thermogenic mechanisms, which can substantially affect whole body metabolism and weight gain. In this review we will describe the role of Sarcolipin-mediated uncoupling of Sarcoplasmic Reticulum Calcium ATPase (SERCA) as a potential mechanism for increased energy expenditure both during cold and diet-induced thermogenesis.
登录
查看更多内容
影响因子：
3.4
作者：
Arruda, Ana Paula;Nigro, Mariana;de Meis, Leopoldo
通讯作者：
de Meis, Leopoldo
影响因子：
4.8
作者：
Arruda, Ana Paula;Ketzer, Luisa A.;de Meis, Leopoldo
通讯作者：
de Meis, Leopoldo
DOI：
10.1073/pnas.0707722104
发表时间：
2007-11-06
影响因子：
11.1
作者：
Babu, Gopal J.;Bhupathy, Poornima;Periasamy, Muthu
通讯作者：
Periasamy, Muthu
DOI：
10.1111/j.1749-6632.1998.tb08325.x
发表时间：
1998-01-01
期刊：
MOLECULAR MECHANISMS OF FEVER
影响因子：
--
作者：
Cannon, B;Houstek, J;Nedergaard, J
通讯作者：
Nedergaard, J
影响因子：
29
作者：
Kozak LP
通讯作者：
Kozak LP