Microbial antigen encounter during a preweaning interval is critical for tolerance to gut bacteria.
Microbial antigen encounter during a preweaning interval is critical for tolerance to gut bacteria.
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DOI：
10.1126/sciimmunol.aao1314
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发表时间：
2017-12-15
影响因子：
24.8
通讯作者：
Newberry RD
中科院分区：
文献类型：
--
作者：
Knoop KA;Gustafsson JK;McDonald KG;Kulkarni DH;Coughlin PE;McCrate S;Kim D;Hsieh CS;Hogan SP;Elson CO;Tarr PI;Newberry RD
我们与居住在胃肠道中的数万亿微生物有着互惠互利的关系。然而，维持这种关系需要认识到这些生物是和蔼可亲的，并在敌对环境中遇到这些生物时抑制炎症反应。免疫系统如何以及何时对我们的肠道微生物成员产生耐受性尚不清楚。在这里，我们确定了一个特定的断奶前的间隔，肠道微生物抗原遇到的免疫系统诱导抗原特异性耐受肠道细菌。有趣的是，对于一些细菌分类群，与免疫系统的生理接触仅限于此间隔，尽管在此间隔之外的稍后时间肠腔中有大量这些分类群。在此断奶前间隔期间诱导的对肠道细菌的抗原特异性耐受性是稳定的并且维持，即使这些分类群在以后的生活中在炎症环境中遇到。然而，在该间隔期间抑制微生物抗原相遇或将这些相遇延长到超过正常间隔，导致在炎症环境中再次相遇时不能诱导对肠道细菌的耐受性和稳健的抗原特异性效应子应答。因此，我们已经确定了一个定义的断奶前间隔，这对于发展对肠道细菌的耐受性和保持与肠道微生物群的互利关系至关重要。
We have a mutually beneficial relationship with the trillions of microorganisms inhabiting our gastrointestinal tract. However, maintaining this relationship requires recognizing these organisms as affable and restraining inflammatory responses to these organisms when encountered in hostile settings. How and when the immune system develops tolerance to our gut microbial members is not well understood. Here we identify a specific pre-weaning interval in which gut microbial antigens are encountered by the immune system to induce antigen specific tolerance to gut bacteria. Intriguingly for some bacterial taxa, physiologic encounters with the immune system are restricted to this interval, despite abundance of these taxa in the gut lumen at later times outside this interval. Antigen specific tolerance to gut bacteria induced during this pre-weaning interval is stable and maintained even if these taxa are encountered later in life in an inflammatory setting. However, inhibiting microbial antigen encounter during this interval or extending these encounters beyond the normal interval, results in a failure to induce tolerance and robust antigen specific effector responses to gut bacteria upon reencounter in an inflammatory setting. Thus, we have identified a defined pre-weaning interval critical for developing tolerance to gut bacteria and maintaining the mutually beneficial relationship with our gut microbiota.
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影响因子：
32.4
作者：
Hou, Baidong;Reizis, Boris;DeFranco, Anthony L.
通讯作者：
DeFranco, Anthony L.
影响因子：
2.6
作者：
Ballard, Olivia;Morrow, Ardythe L.
通讯作者：
Morrow, Ardythe L.
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
DOI：
10.4049/jimmunol.1502126
发表时间：
2016-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Carey AJ;Gracias DT;Thayer JL;Boesteanu AC;Kumova OK;Mueller YM;Hope JL;Fraietta JA;van Zessen DB;Katsikis PD
通讯作者：
Katsikis PD
影响因子：
3.1
作者：
Cohavy, O;Bruckner, D;Braun, J
通讯作者：
Braun, J