Bone marrow mesenchymal stem cells interact with head and neck squamous cell carcinoma cells to promote cancer progression and drug resistance.
Bone marrow mesenchymal stem cells interact with head and neck squamous cell carcinoma cells to promote cancer progression and drug resistance.
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骨髓间充质干细胞与头颈鳞状细胞癌细胞相互作用促进癌症进展和耐药性
DOI：
10.1016/j.neo.2020.11.012
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Bhowmick NA
中科院分区：
文献类型：
--
作者：
Liu C;Billet S;Choudhury D;Cheng R;Haldar S;Fernandez A;Biondi S;Liu Z;Zhou H;Bhowmick NA
Head and neck cancers are often diagnosed at later stages with poor outcomes. Mesenchymal stem cells (MSC) are recruited to primary tumor sites where they can have pro- and antitumorigenic influence. In trying to better understand the dynamics between MSC and cancer cells, we found that head and neck cancer-MSC exposure resulted in mesenchymal features, elevated proliferation rate, and were more motile, like the same cells that fused with MSC. We orthotopically grafted the parental head and neck cancer cells, those fused with MSC, or those exposed to MSC into the tongues of mice. The cancer cells originally incubated with MSC developed larger more aggressive tumors compared to the parental cell line. RNA sequencing analysis revealed the expression of genes associated with drug resistance in the cancer cells exposed to MSC compared to parental cancer cells. Strikingly, MSC exposed cancer cell lines developed paclitaxel resistance that could be maintained up to 30 d after the initial co-incubation period. The secretory profile of the MSC suggested IL-6 to be a potential mediator of epigenetic imprinting on the head and neck cancer cells. When the MSC-imprinted cancer cells were exposed to the demethylation agent, 5-aza-2’deoxycytidine, it restored the expression of the drug resistance genes to that of parental cells. This study demonstrated that the recognized recruitment of MSC to tumors could impart multiple protumorigenic properties including chemotherapy resistance like that observed in the relatively rare event of cancer/MSC cell fusion.
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影响因子：
11.2
作者：
Nakamizo, A;Marini, F;Lang, FF
通讯作者：
Lang, FF
影响因子：
3.4
作者：
Han, Myung Woul;Lee, Jong Cheol;Kim, Sang Yoon
通讯作者：
Kim, Sang Yoon
影响因子：
11.2
作者：
Loebinger MR;Eddaoudi A;Davies D;Janes SM
通讯作者：
Janes SM
影响因子：
13.6
作者：
Gast CE;Silk AD;Zarour L;Riegler L;Burkhart JG;Gustafson KT;Parappilly MS;Roh-Johnson M;Goodman JR;Olson B;Schmidt M;Swain JR;Davies PS;Shasthri V;Iizuka S;Flynn P;Watson S;Korkola J;Courtneidge SA;Fischer JM;Jaboin J;Billingsley KG;Lopez CD;Burchard J;Gray J;Coussens LM;Sheppard BC;Wong MH
通讯作者：
Wong MH
影响因子：
24.5
作者：
De Boeck, Astrid;Pauwels, Patrick;De Wever, Olivier
通讯作者：
De Wever, Olivier