Multifunctional plasmonic shell-magnetic core nanoparticles for targeted diagnostics, isolation, and photothermal destruction of tumor cells.
Multifunctional plasmonic shell-magnetic core nanoparticles for targeted diagnostics, isolation, and photothermal destruction of tumor cells.
复制标题
DOI：
10.1021/nn2045246
复制
发表时间：
2012-02-28
期刊：
影响因子：
17.1
通讯作者：
Ray PC
中科院分区：
文献类型：
--
作者：
Fan Z;Shelton M;Singh AK;Senapati D;Khan SA;Ray PC
癌症是当今人类医疗保健面临的最大挑战。癌症每年造成760万人死亡，经济损失约1万亿美元。癌症的早期诊断和有效治疗对于挽救生命至关重要。在这些需求的推动下，我们报告了一种多功能等离子体壳-磁芯纳米技术驱动的方法的发展，用于癌细胞的靶向诊断、分离和光热破坏。实验数据显示，适体缀合的等离子体/磁性纳米颗粒可用于靶向成像和从不同癌细胞的混合物中磁性分离特定种类的细胞。使用670 nm光以2.5 W/cm 2进行10分钟的靶向光热实验对大多数癌细胞造成了选择性的不可修复的细胞损伤。我们还表明，适体缀合的基于磁性/等离子体纳米颗粒的光热破坏癌细胞是高度选择性的。我们讨论了可能的机制和工作原理的目标成像，分离，光热破坏使用磁/等离子体纳米技术。
Cancer is the greatest challenge in human healthcare today. Cancer causes 7.6 million deaths and economic losses of around 1 trillion dollars every year. Early diagnosis and effective treatment of cancer are crucial for saving lives. Driven by these needs, we report the development of a multifunctional plasmonic shell–magnetic core nanotechnology-driven approach for the targeted diagnosis, isolation, and photothermal destruction of cancer cells. Experimental data show that aptamer-conjugated plasmonic/magnetic nanoparticles can be used for targeted imaging and magnetic separation of a particular kind of cell from a mixture of different cancer cells. A targeted photothermal experiment using 670-nm light at 2.5 W/cm2 for 10 minutes resulted selective irreparable cellular damage to most of the cancer cells. We also showed that the aptamer-conjugated magnetic/plasmonic nanoparticle-based photothermal destruction of cancer cells is highly selective. We discuss the possible mechanism and operating principle for the targeted imaging, separation, and photothermal destruction using magnetic/plasmonic nanotechnology.
登录
查看更多内容
影响因子：
17.1
作者：
Kumar R;Roy I;Ohulchanskky TY;Vathy LA;Bergey EJ;Sajjad M;Prasad PN
通讯作者：
Prasad PN
影响因子：
17.1
作者：
Kievit FM;Veiseh O;Fang C;Bhattarai N;Lee D;Ellenbogen RG;Zhang M
通讯作者：
Zhang M
影响因子：
17.1
作者：
Bhirde, Ashwin A.;Patel, Vyomesh;Gavard, Julie;Zhang, Guofeng;Sousa, Alioscka A.;Masedunskas, Andrius;Leapman, Richard D.;Weigert, Roberto;Gutkind, J. Silvio;Rusling, James F.
通讯作者：
Rusling, James F.
影响因子：
4.7
作者：
Bae, Ki Hyun;Kim, Young Beom;Park, Tae Gwan
通讯作者：
Park, Tae Gwan
影响因子：
13.3
作者：
Gobin, Andre M.;Watkins, Emily M.;Quevedo, Elizabeth;Colvin, Vicki L.;West, Jennifer L.
通讯作者：
West, Jennifer L.