Predicting neurodegenerative disease in idiopathic rapid eye movement (REM) sleep behavior disorder: Conference proceedings, REM Sleep Behavior Symposium 2011
Predicting neurodegenerative disease in idiopathic rapid eye movement (REM) sleep behavior disorder: Conference proceedings, REM Sleep Behavior Symposium 2011
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预测特发性快速眼动 (REM) 睡眠行为障碍中的神经退行性疾病：会议记录，2011 年 REM 睡眠行为研讨会
DOI：
10.1111/j.1479-8425.2012.00557.x
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发表时间：
2013
影响因子：
1.1
通讯作者：
R. Postuma
中科院分区：
文献类型：
--
作者：
R. Postuma
快速眼动睡眠行为障碍（rapideyemovitionsleepbehaviordisorder，RBD）是一种以快速眼动睡眠期的梦境行为为特征的异眠症，通常与桥脑延髓结构的损害有关。特发性RBD是神经退行性疾病的一个公认的风险因素;至少40-65%的特发性RBD患者将在10年内发展出明确的神经退行性表型。这几乎总是一种“突触核蛋白病”（帕金森病，路易体痴呆或多系统萎缩）。通常，患者会发展为帕金森综合征和认知障碍重叠的综合征。RBD预测疾病的能力对神经保护治疗的发展具有重要意义，通过为神经保护试验提供高风险前驱组。此外，它还允许测试神经退行性变的其他预测标志物。最近的前瞻性研究发现，基线嗅觉异常的特发性RBD患者发生神经退行性疾病的5年风险为65%，而嗅觉正常的患者为14%。色觉异常者患神经退行性疾病的风险为74%，而视力正常者为26%。此外，黑质的神经影像学标志物，包括多巴胺能功能成像和经颅超声已经能够预测RBD中即将发生的定义的神经退行性疾病，尽管灵敏度和提前时间尚未确定。未来的研究将继续扩大神经退行性变的预测标志物列表，并将更好地定义前驱标志物的特异性，灵敏度和前置时间。
Rapid eye movement sleep behavior disorder (RBD) is a parasomnia characterized by dream enactment behavior during rapid eye movement sleep, which is generally related to damage of pontomedullary structures. Idiopathic RBD is a well-established risk factor for neurodegenerative disease; at least 40-65% of patients with idiopathic RBD will develop a defined neurodegenerative phenotype over 10 years. This is almost always a “synucleinopathy” (Parkinson’s disease, dementia with Lewy bodies, or multiple system atrophy). Often, patients develop a syndrome with overlapping parkinsonism and cognitive impairment. The ability of RBD to predict disease has major implications for development of neuroprotective therapy, by providing a high-risk prodromal group for neuro-protective trials. In addition, it allows testing of other predictive markers of neurodegeneration. Recent prospective studies found that idiopathic RBD patients with abnormal olfaction at baseline had a 65% 5-year risk of developing neurodegenerative disease, compared with a 14% risk in those with normal olfaction. Those with abnormal color vision had a 74% risk of neurodegenerative disease compared with 26% in those with normal vision. Additionally, neuroimaging markers of the sub-stantia nigra including dopaminergic functional imaging and transcranial ultrasound have been able to predict imminent development of defined neurodegenerative disease in RBD, although sensitivity and lead time have not been established. Future studies will continue to expand the list of predictive markers of neurodegeneration and will better define specificity, sensitivity, and lead time of prodromal markers.
影响因子：
6.4
作者：
Orimo, Satoshi;Takahashi, Atsushi;Takahashi, Hitoshi
通讯作者：
Takahashi, Hitoshi