The Two-Faced Cytokine IL-6 in Host Defense and Diseases.
The Two-Faced Cytokine IL-6 in Host Defense and Diseases.
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DOI：
10.3390/ijms19113528
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发表时间：
2018-11-09
影响因子：
5.6
通讯作者：
Kishimoto T
中科院分区：
文献类型：
--
作者：
Narazaki M;Kishimoto T
白细胞介素-6（IL-6）是由感染或损伤病灶局部产生的，并通过血流输送到全身，迅速激活宿主防御系统以执行各种功能。然而，IL-6的过度或持续产生涉及各种疾病。在疾病中，IL-6抑制策略始于抗IL-6受体抗体托珠单抗（TCZ）的开发。该抗体对Castleman病、类风湿性关节炎和幼年特发性关节炎有显著疗效。2017年，TCZ被证明对巨细胞动脉炎，大动脉炎和细胞因子释放综合征有效，开创了治疗这些疾病的新时代。在本研究中，IL-6和各种病理条件下的防御功能进行了比较。此外，TCZ已被批准用于治疗的疾病进行了总结，增加TCZ的各种疾病的标签外使用的最新结果进行了审查，并讨论了IL-6抑制可能具有有益作用的条件。鉴于IL-6参与许多病理学，可以通过IL-6抑制改善的疾病将扩大。然而，在临床实践中应始终牢记IL-6在宿主防御中的重要作用。
Interleukein-6 (IL-6), is produced locally from infectious or injured lesions and is delivered to the whole body via the blood stream, promptly activating the host defense system to perform diverse functions. However, excessive or sustained production of IL-6 is involved in various diseases. In diseases, the IL-6 inhibitory strategy begins with the development of the anti-IL-6 receptor antibody, tocilizumab (TCZ). This antibody has shown remarkable effects on Castleman disease, rheumatoid arthritis and juvenile idiopathic arthritis. In 2017, TCZ was proven to work effectively against giant cell arteritis, Takayasu arteritis and cytokine releasing syndrome, initiating a new era for the treatment of these diseases. In this study, the defensive functions of IL-6 and various pathological conditions are compared. Further, the diseases of which TCZ has been approved for treatment are summarized, the updated results of increasing off-label use of TCZ for various diseases are reviewed and the conditions for which IL-6 inhibition might have a beneficial role are discussed. Given the involvement of IL-6 in many pathologies, the diseases that can be improved by IL-6 inhibition will expand. However, the important role of IL-6 in host defense should always be kept in mind in clinical practice.
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影响因子：
9.9
作者：
Araki M;Matsuoka T;Miyamoto K;Kusunoki S;Okamoto T;Murata M;Miyake S;Aranami T;Yamamura T
通讯作者：
Yamamura T
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
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作者：
De Benedetti, Fabrizio;Rucci, Nadia;Teti, Anna
通讯作者：
Teti, Anna
影响因子：
27.4
作者：
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通讯作者：
Eguchi, K
影响因子：
6.1
作者：
Chourbaji, Sabine;Urani, Alexandre;Gass, Peter
通讯作者：
Gass, Peter