Circadian rhythms and pain.

Circadian rhythms and pain.
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DOI:
10.1016/j.neubiorev.2021.08.004
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发表时间:
2021-10
影响因子:
8.2
通讯作者:
Nelson RJ
Nelson RJ
中科院分区:
医学1区
文献类型:
--
作者:
Bumgarner JR;Walker WH 2nd;Nelson RJ

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本综述的目的是为昼夜节律和疼痛系统之间关系的性质和重要性提供一个新颖的视角。我们提供:1)昼夜节律和疼痛系统的概述,2)对证明疼痛系统内昼夜节律的直接和相关证据的回顾; 3)强调需要考虑昼夜节律破坏和适应不良疼痛的拟议反馈回路的作用的观点; 4)对昼夜节律与疼痛之间关系本质的看法。总之,我们认为没有一个单一的基因座负责产生疼痛系统的昼夜节律。相反,疼痛的昼夜节律是整个疼痛系统中存在的分布式节律的复杂结果,特别是下行疼痛调节系统的节律,以及与其相互作用的系统的节律,包括阿片类药物、内分泌和免疫系统。
The goal of this review is to provide a novel perspective on the nature and importance of the relationship between the circadian and pain systems. We provide: 1) An overview of the circadian and pain systems, 2) a review of direct and correlative evidence that demonstrates diurnal and circadian rhythms within the pain system; 3) a perspective highlighting the need to consider the role of a proposed feedback loop of circadian rhythm disruption and maladaptive pain; 4) a perspective on the nature of the relationship between circadian rhythms and pain. In summary, we propose that there is no single locus responsible for producing the circadian rhythms of the pain system. Instead, circadian rhythms of pain are a complex result of the distributed rhythms present throughout the pain system, especially those of the descending pain modulatory system, and the rhythms of the systems with which it interacts, including the opioid, endocrine, and immune systems.
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