Pain control by melatonin: Physiological and pharmacological effects.
Pain control by melatonin: Physiological and pharmacological effects.
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DOI：
10.3892/etm.2016.3565
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发表时间：
2016-10
影响因子：
2.7
通讯作者：
Huang WJ
中科院分区：
文献类型：
--
作者：
Chen WW;Zhang X;Huang WJ
疼痛和焦虑是对许多有害或有害刺激最常见的神经反应，其临床管理往往具有挑战性。许多常用的吗啡类药物、非类固醇抗炎药和对乙酰氨基酚虽然对治疗疼痛有效，但会导致患者遭受一些不想要的副作用。褪黑素由松果体产生，是一种黑暗激素，参与控制昼夜节律，并具有许多药理作用。褪黑素通过细胞膜上的MT1/MT2褪黑素受体和RZR/ROR核孤儿受体介导其作用。慢性疼痛综合征通常与昼夜节律和生物节律的不同步有关，这也会导致睡眠-觉醒周期的紊乱。褪黑素介导的镇痛作用似乎涉及β-内啡肽、GABA受体、阿片受体和一氧化氮-精氨酸途径。褪黑激素作为镇痛和抗焦虑剂的有效性已在各种疼痛动物模型中得到证实，这导致褪黑激素在临床上用于不同的病理条件和接受手术的患者。褪黑素被发现是有效的在许多这些情况下作为抗焦虑和镇痛剂，表明其临床应用。
Pain and anxiety are the most common neurological responses to many harmful or noxious stimuli and their management clinically is often challenging. Many of the frequently used morphine-based drugs, non-steroid anti-inflammatory drugs and acetaminophen, while efficient for treating pain, lead to patients suffering from several unwanted side effects. Melatonin, produced from the pineal body is a hormone of darkness, is involved in the control of circadian rhythms, and exerts a number of pharmacological effects. Melatonin mediates its actions through MT1/MT2 melatonin receptors on the cell membrane and also through RZR/ROR nuclear orphan receptors. Chronic pain syndromes are often associated with the desynchronization of circadian and biological rhythms, which also cause disturbances in the sleep-wake cycle. Melatonin-mediated analgesic effects seem to involve β-endorphins, GABA receptor, opioid receptors and the nitric oxide-arginine pathway. The effectiveness of melatonin as an analgesic and anxiolytic agent has been demonstrated in various animal models of pain and this led to the use of melatonin clinically in different pathological conditions and also in patients undergoing surgery. Melatonin was found to be effective in many of these cases as an anxiolytic and analgesic agent, indicating its clinical application.
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影响因子：
10.3
作者：
Hussain, Saad Abdul-Rehman;Al-Khalifa, Ihab Ibrahim;Gorial, Faiq Isho
通讯作者：
Gorial, Faiq Isho
影响因子：
2.9
作者：
de Zanette SA;Vercelino R;Laste G;Rozisky JR;Schwertner A;Machado CB;Xavier F;de Souza IC;Deitos A;Torres IL;Caumo W
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影响因子：
6.1
作者：
LAKIN, ML;MILLER, CH;WINTERS, WD
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WINTERS, WD
影响因子：
5
作者：
Hernandez-Pacheco, Alfonso;Ivonne Araiza-Saldana, Claudia;Mixcoatl-Zecuatl, Teresa
通讯作者：
Mixcoatl-Zecuatl, Teresa
影响因子：
3.4
作者：
Hartz, Ingeborg;Furu, Kari;Skurtveit, Svetlana
通讯作者：
Skurtveit, Svetlana