Primary cilia are required for the persistence of memory and stabilization of perineuronal nets.
Primary cilia are required for the persistence of memory and stabilization of perineuronal nets.
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DOI：
10.1016/j.isci.2021.102617
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发表时间：
2021-06-25
期刊：
影响因子：
5.8
通讯作者：
Radulovic J
中科院分区：
文献类型：
--
作者：
Jovasevic V;Zhang H;Sananbenesi F;Guedea AL;Soman KV;Wiktorowicz JE;Fischer A;Radulovic J
情景记忆的形成需要多个海马机制在不同的时间尺度上运作。记忆形成（突触巩固）的早期机制已被广泛研究。然而，当记忆在皮层回路中稳定时，维持海马体活动的延迟机制尚未得到很好的理解。在这里，我们证明了与早期和延迟反应基因的瞬时表达相反，细胞骨架和细胞外基质相关基因的表达即使在遥远的时间点也保持动态。最深刻的表达变化集中在原发性纤毛相关基因和胶原蛋白基因周围。这些基因最有可能通过稳定海马背区CA1亚场的神经网络来促进记忆，正如对初级纤毛或神经网络的靶向破坏所揭示的那样。研究结果表明，非突触、初级纤毛介导的机制是上下文记忆持久性所必需的。在记忆巩固过程中细胞骨架的变化逐渐扩大初级纤毛相关基因在远程记忆和近期记忆中上调初级纤毛支持海马在长期巩固中的作用初级纤毛在pnn神经科学的组织和/或稳定性中起关键作用；细胞神经科学;认知神经科学
It is well established that the formation of episodic memories requires multiple hippocampal mechanisms operating on different time scales. Early mechanisms of memory formation (synaptic consolidation) have been extensively characterized. However, delayed mechanisms, which maintain hippocampal activity as memories stabilize in cortical circuits, are not well understood. Here we demonstrate that contrary to the transient expression of early- and delayed-response genes, the expression of cytoskeleton- and extracellular matrix-associated genes remains dynamic even at remote time points. The most profound expression changes clustered around primary cilium-associated and collagen genes. These genes most likely contribute to memory by stabilizing perineuronal nets in the dorsohippocampal CA1 subfield, as revealed by targeted disruptions of the primary cilium or perineuronal nets. The findings show that nonsynaptic, primary cilium-mediated mechanisms are required for the persistence of context memory. Changes in the cytoskeleton progressively expand during memory consolidation Primary cilium-associated genes are upregulated in remote vs recent memory The primary cilium supports the role of the hippocampus in long-term consolidation The primary cilium has a critical role in the organization and/or stability of PNNs Neuroscience; Cellular neuroscience; Cognitive neuroscience
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影响因子：
3.7
作者：
Berbari NF;Malarkey EB;Yazdi SM;McNair AD;Kippe JM;Croyle MJ;Kraft TW;Yoder BK
通讯作者：
Yoder BK
影响因子：
2
作者：
Daumas, S;Halley, H;Lassalle, JM
通讯作者：
Lassalle, JM
影响因子：
3.5
作者：
Barnes, Philip;Kirtley, Anne;Thomas, Kerrie L.
通讯作者：
Thomas, Kerrie L.
DOI：
10.1073/pnas.0804558105
发表时间：
2008-09-02
影响因子：
11.1
作者：
Breunig, Joshua J.;Sarkisian, Matthew R.;Town, Terrence
通讯作者：
Town, Terrence
影响因子：
5.3
作者：
Amador-Arjona, Alejandro;Elliott, Jimmy;Terskikh, Alexey V.
通讯作者：
Terskikh, Alexey V.