A review on immunomodulatory effects of BPA analogues.
A review on immunomodulatory effects of BPA analogues.
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DOI：
10.1007/s00204-023-03519-y
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发表时间：
2023-07
影响因子：
6.1
通讯作者：
中科院分区：
文献类型：
--
作者：
双酚A（BPA）是一种已知的内分泌干扰物，存在于人类日常接触的许多消费品中。由于对BPA安全性的日益关注以及限制其使用的新立法的引入，工业界通过采用具有类似聚合物形成特性的新的、研究较少的BPA类似物来应对。一些BPA类似物已经显示出与BPA类似的作用，例如，通过对各种核受体如雌激素（ER）、雄激素（AR）、糖皮质激素（GR）、芳烃（AhR）和甾烷X受体（PXR）的激动或拮抗行为导致内分泌干扰。由于欧洲食品安全局（EFSA）发布了BPA的重新评估草案，并将BPA的临时每日耐受摄入量（t-TDI）从4 mg/kg体重/天大幅降低至0.2 ng/kg体重/天，因为人们越来越关注BPA的毒性，包括其破坏免疫系统过程的潜力，我们对环境中丰富的BPA类似物的免疫调节活性进行了全面的综述。该综述的结果表明，BPA类似物可能会影响先天和后天免疫系统，并可能导致各种免疫介导的疾病，如超敏反应，过敏和人体微生物组的破坏。
Bisphenol A (BPA) is a known endocrine disruptor found in many consumer products that humans come into contact with on a daily basis. Due to increasing concerns about the safety of BPA and the introduction of new legislation restricting its use, industry has responded by adopting new, less studied BPA analogues that have similar polymer-forming properties. Some BPA analogues have already been shown to exhibit effects similar to BPA, for example, contributing to endocrine disruption through agonistic or antagonistic behaviour at various nuclear receptors such as estrogen (ER), androgen (AR), glucocorticoid (GR), aryl hydrocarbon (AhR), and pregnane X receptor (PXR). Since the European Food Safety Authority (EFSA) issued a draft re-evaluation of BPA and drastically reduced the temporary tolerable daily intake (t-TDI) of BPA from 4 mg/kg body weight/day to 0.2 ng/kg body weight/day due to increasing concern about the toxic properties of BPA, including its potential to disrupt immune system processes, we conducted a comprehensive review of the immunomodulatory activity of environmentally abundant BPA analogues. The results of the review suggest that BPA analogues may affect both the innate and acquired immune systems and can contribute to various immune-mediated conditions such as hypersensitivity reactions, allergies, and disruption of the human microbiome.
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影响因子：
3.7
作者：
Chassaing B;Srinivasan G;Delgado MA;Young AN;Gewirtz AT;Vijay-Kumar M
通讯作者：
Vijay-Kumar M
影响因子：
--
作者：
Bodin J;Kocbach Bølling A;Wendt A;Eliasson L;Becher R;Kuper F;Løvik M;Nygaard UC
通讯作者：
Nygaard UC
父母接触双酚 A 及其类似物会影响斑马鱼后代的免疫力
DOI：
10.1016/j.scitotenv.2017.08.057
发表时间：
2018-01-01
期刊：
The Science of the total environment
影响因子：
--
作者：
Dong X;Zhang Z;Meng S;Pan C;Yang M;Wu X;Yang L;Xu H
通讯作者：
Xu H
影响因子：
4.1
作者：
Alabi, A.;Caballero-Casero, N.;Rubio, S.
通讯作者：
Rubio, S.
影响因子：
8.8
作者：
Brulport, Axelle;Lencina, Corinne;Guzylack-Piriou, Laurence
通讯作者：
Guzylack-Piriou, Laurence