In vivo MR determination of water diffusion coefficients and diffusion anisotropy: correlation with structural alteration in gliomas of the cerebral hemispheres.
In vivo MR determination of water diffusion coefficients and diffusion anisotropy: correlation with structural alteration in gliomas of the cerebral hemispheres.
复制标题
体内 MR 测定水扩散系数和扩散各向异性：与大脑半球胶质瘤结构改变的相关性。
DOI：
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复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
A. T. Betley
中科院分区：
文献类型：
--
作者：
J. Brunberg;T. Chenevert;P. Mckeever;D. Ross;L. Junck;K. Muraszko;R. Dauser;J. Pipe;A. T. Betley
目的
确定脑胶质瘤患者的水扩散系数或扩散各向异性与MR定义的正常或异常脑实质区域之间是否存在关系。
方法
在40例脑胶质瘤患者中，使用运动不敏感的自旋回波序列在三个正交方向上以两个梯度强度设置顺序应用，在单个感兴趣列中表征扩散。在沿柱沿着的128个点处，针对三个正交轴导出表观扩散系数（ADC）。然后计算肿瘤或邻近实质内9个MR确定的感兴趣区域的平均ADC和扩散各向异性指数（IDA =扩散系数最大-最小/扩散平均值）。
结果
在脑水肿中，平均ADC（所有ADC均为10（-7）cm 2/s）为138 +/- 24（正常白色物质为83 +/- 6），平均IDA为0.26 +/- 0.14（正常白色物质为0.45 +/- 0.17）。实体增强中心肿瘤平均ADC为131 +/- 25，平均IDA为0.15 +/- 0.10。实体增强肿瘤边缘平均ADC为131 +/- 25，IDA为0.25 +/- 0.20。囊肿或坏死的平均ADC为235 ± 35，IDA为0.07 ± 0.04。
结论
在脑胶质瘤中，ADC和IDA的测定提供了常规MR成像无法提供的信息。ADC和IDA测定允许区分正常白色物质、坏死或囊肿形成区域、水肿区域和实体增强肿瘤。使用标准MR硬件，可以在感兴趣的运动不敏感列内快速可靠地表征ADC。
PURPOSE
To determine whether a relationship exists between water diffusion coefficients or diffusion anisotropy and MR-defined regions of normal or abnormal brain parenchyma in patients with cerebral gliomas.
METHODS
In 40 patients with cerebral gliomas, diffusion was characterized in a single column of interest using a motion-insensitive spin-echo sequence that was applied sequentially at two gradient strength settings in three orthogonal directions. Apparent diffusion coefficients (ADCs) were derived for the three orthogonal axes at 128 points along the column. An average ADC and an index of diffusion anisotropy (IDA = diffusion coefficientmax-min/diffusionmean) was than calculated for any of nine MR-determined regions of interest within the tumor or adjacent parenchyma.
RESULTS
In cerebral edema, mean ADC (all ADCs as 10(-7) cm2/s) was 138 +/- 24 (versus 83 +/- 6 for normal white matter) with mean IDA of 0.26 +/- 0.14 (versus 0.45 +/- 0.17 for normal white matter). Solid enhancing central tumor mean ADC was 131 +/- 25 with mean IDA of 0.15 +/- 0.10. Solid enhancing tumor margin mean ADC was 131 +/- 25, with IDA of 0.25 +/- 0.20. Cyst or necrosis mean ADC was 235 +/- 35 with IDA of 0.07 +/- 0.04.
CONCLUSION
In cerebral gliomas ADC and IDA determinations provide information not available from routine MR imaging. ADC and IDA determinations allow distinction between normal white matter, areas of necrosis or cyst formation, regions of edema, and solid enhancing tumor. ADCs can be quickly and reliably characterized within a motion-insensitive column of interest with standard MR hardware.
影响因子：
6.7
作者：
JOHNSON, GA;MAKI, JH
通讯作者：
MAKI, JH
DOI：
--
发表时间：
1992-07
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
D. Chien;K. K. Kwong-K.;D. R. Gress;F. Buonanno;R. B. Buxton;B. R. Rosen
通讯作者：
D. Chien;K. K. Kwong-K.;D. R. Gress;F. Buonanno;R. B. Buxton;B. R. Rosen