Endothelial microparticles act as novel diagnostic and therapeutic biomarkers of circulatory hypoxia-related diseases: a literature review.
Endothelial microparticles act as novel diagnostic and therapeutic biomarkers of circulatory hypoxia-related diseases: a literature review.
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内皮微粒作为循环缺氧相关疾病的新型诊断和治疗生物标志物：文献综述
DOI：
10.1111/jcmm.13125
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发表时间：
2017-09
影响因子：
5.3
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Deng F;Wang S;Zhang L
循环性缺氧相关疾病（CHRD），包括急性冠状动脉综合征、中风和器官移植，由于其高发病率和死亡率而引起越来越多的关注。越来越多的证据表明，缺氧诱导的氧化应激、凝血、炎症和血管生成在CHRD相关血管内皮损伤的生理和病理过程中起着极其重要的作用。有趣的是，缺氧，甚至缺氧诱导的氧化应激，凝血和炎症都可以诱导内皮微粒（EMP）的释放。从活化或凋亡的内皮细胞（EC）脱落的EMP反映了EC损伤的程度，并且在几种CHRD中发现EMP水平升高。此外，EMP在细胞间通讯和功能中发挥重要作用，已证实具有促凝血、促炎症、血管生成和其他功能，影响病理过程。这些结果表明，EMP和CHRD有非常密切的关系，EMP可能有助于识别CHRD表型和分层疾病的严重程度，以改善发展CHRD的风险分层，以更好地确定预防策略和改善CHRD患者的预后特征。本文综述了EMPs在CHRD的诊断、分期、治疗和临床预后中的已知和潜在作用。
Circulatory hypoxia‐related diseases (CHRDs), including acute coronary syndromes, stroke and organ transplantation, attract increased attention due to high morbidity and mortality. Mounting evidence shows that hypoxia‐induced oxidative stress, coagulation, inflammation and angiogenesis play extremely important roles in the physiological and pathological processes of CHRD‐related vascular endothelial injury. Interestingly, hypoxia, even hypoxia‐induced oxidative stress, coagulation and inflammation can all induce release of endothelial microparticles (EMPs). EMPs, shed from activated or apoptotic endothelial cells (ECs), reflect the degree of EC damage, and elevated EMP levels are found in several CHRDs. Furthermore, EMPs, which play an important role in cell‐to‐cell communication and function, have confirmed pro‐coagulant, proinflammatory, angiogenic and other functions, affecting pathological processes. These findings suggest that EMPs and CHRDs have a very close relationship, and EMPs may help to identify CHRD phenotypes and stratify the severity of disease, to improve risk stratification for developing CHRDs, to better define prophylactic strategies and to ameliorate prognostic characterization of patients with CHRDs. This review summarizes the known and potential roles of EMPs in the diagnosis, staging, treatment and clinical prognosis of CHRDs.
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影响因子：
3.7
作者：
Chiva-Blanch G;Suades R;Crespo J;Peña E;Padró T;Jiménez-Xarrié E;Martí-Fàbregas J;Badimon L
通讯作者：
Badimon L
影响因子：
6.7
作者：
Diehl, Philipp;Nagy, Ferenc;Moser, Martin
通讯作者：
Moser, Martin
影响因子：
20.3
作者：
Bardin, N;Anfosso, F;Dignat-George, F
通讯作者：
Dignat-George, F
DOI：
10.1161/atvbaha.114.303927
发表时间：
2015-02-01
影响因子：
8.7
作者：
Arderiu, Gemma;Pena, Esther;Badimon, Lina
通讯作者：
Badimon, Lina
影响因子：
3.6
作者：
Chrisostomidis, Chrisostomos;Konofaos, Petros;Papadopoulos, Othon
通讯作者：
Papadopoulos, Othon