Ganglioside GM1 and the Central Nervous System.
Ganglioside GM1 and the Central Nervous System.
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DOI：
10.3390/ijms24119558
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发表时间：
2023-05-31
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
神经节苷脂(GM1)是中枢神经系统(CNS)细胞表面的主要糖鞘糖脂之一。它的表达水平、分布模式和脂质成分取决于细胞和组织类型、发育阶段和疾病状态，这表明GM1在各种神经和神经病理过程中具有广泛的功能。本文综述了GM1在脑发育和脑活动中的作用，如细胞分化、神经发生、神经再生、信号转导、记忆和认知，以及这些功能的分子基础和机制。总体而言，GM1对中枢神经系统具有保护作用。此外，本文还探讨了GM1与阿尔茨海默病、帕金森病、GM1神经节苷脂沉着症、亨廷顿病、癫痫和癫痫、肌萎缩侧索硬化症、抑郁症、酒精依赖等神经系统疾病的关系，以及GM1在这些疾病中的功能作用和治疗应用。最后，讨论了目前阻碍对GM1进行更深入研究和理解的障碍以及该领域的未来发展方向。
GM1 is one of the major glycosphingolipids (GSLs) on the cell surface in the central nervous system (CNS). Its expression level, distribution pattern, and lipid composition are dependent upon cell and tissue type, developmental stage, and disease state, which suggests a potentially broad spectrum of functions of GM1 in various neurological and neuropathological processes. The major focus of this review is the roles that GM1 plays in the development and activities of brains, such as cell differentiation, neuritogenesis, neuroregeneration, signal transducing, memory, and cognition, as well as the molecular basis and mechanisms for these functions. Overall, GM1 is protective for the CNS. Additionally, this review has also examined the relationships between GM1 and neurological disorders, such as Alzheimer’s disease, Parkinson’s disease, GM1 gangliosidosis, Huntington’s disease, epilepsy and seizure, amyotrophic lateral sclerosis, depression, alcohol dependence, etc., and the functional roles and therapeutic applications of GM1 in these disorders. Finally, current obstacles that hinder more in-depth investigations and understanding of GM1 and the future directions in this field are discussed.
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DOI：
10.1111/j.1749-6632.1998.tb09690.x
发表时间：
1998-01-01
期刊：
SPHINGOLIPIDS AS SIGNALING MODULATORS IN THE NERVOUS SYSTEM
影响因子：
--
作者：
Baumgartner, WA;Redmond, JM;Johnston, MV
通讯作者：
Johnston, MV
影响因子：
4.7
作者：
BERRYKRAVIS, E;DAWSON, G
通讯作者：
DAWSON, G
淀粉样蛋白β-肽和神经节对小鼠神经干细胞的影响。
影响因子：
4.4
作者：
Itokazu, Yutaka;Kato-Negishi, Midori;Nakatani, Yoshihiko;Ariga, Toshio;Yu, Robert K.
通讯作者：
Yu, Robert K.
影响因子：
5.1
作者：
Broekman, M. L. D.;Tierney, L. A.;Sena-Esteves, M.
通讯作者：
Sena-Esteves, M.
影响因子：
4.2
作者：
Barrier, L;Page, G;Portoukalian, J
通讯作者：
Portoukalian, J