Effects of amyloid β-peptides and gangliosides on mouse neural stem cells.
Effects of amyloid β-peptides and gangliosides on mouse neural stem cells.
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淀粉样蛋白β-肽和神经节对小鼠神经干细胞的影响。
DOI：
10.1007/s11064-013-1108-y
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发表时间：
2013-10
影响因子：
4.4
通讯作者：
Yu, Robert K.
中科院分区：
文献类型：
--
作者：
Itokazu, Yutaka;Kato-Negishi, Midori;Nakatani, Yoshihiko;Ariga, Toshio;Yu, Robert K.
淀粉样β蛋白（Aβ）与膜脂质的相互作用被认为是阿尔茨海默病中Aβ原纤维形成的早期事件。我们评估了几种假定的生物活性Aβ和神经节苷脂对从胚胎小鼠脑或成年小鼠脑室下区分离的神经干细胞（NSCs）的影响。单独用可溶性Aβ1-40孵育分离的神经干细胞不会引起神经干细胞数量的任何变化，但可溶性Aβ1-42增加了神经干细胞的数量。聚集的Aβ1-40和Aβ1-42增加神经干细胞的数量，而可溶性和聚集的Aβ25-35减少神经干细胞的数量。可溶性Aβ1-40和Aβ1-42不影响凋亡细胞数，而聚集性Aβ1-40和Aβ1-42影响凋亡细胞数。当神经干细胞用GM 1或GD 3和可溶性Aβ1-42的组合处理时，细胞增殖增强，表明GM 1和GD 3以及Aβ参与促进神经干细胞的细胞增殖和存活。这些观察结果表明使用神经节苷脂和Aβ促进NSC增殖的潜在有益作用。
The interaction of amyloid β-proteins (Aβs) with membrane lipids has been postulated as an early event in Aβ fibril formation in Alzheimer’s disease. We evaluated the effects of several putative bioactive Aβs and gangliosides on neural stem cells (NSCs) isolated from embryonic mouse brains or the subventricular zone of adult mouse brains. Incubation of the isolated NSCs with soluble Aβ1–40 alone did not cause any change in the number of NSCs, but soluble Aβ1–42 increased their number. Aggregated Aβ1–40 and Aβ1–42 increased the number of NSCs but soluble and aggregated Aβ25–35 decreased the number. Soluble Aβ1–40 and Aβ1–42 did not affect the number of apoptotic cells but aggregated Aβ1–40 and Aβ1–42 did. When NSCs were treated with a combination of GM1 or GD3 and soluble Aβ1–42, cell proliferation was enhanced, indicating that both GM1 and GD3 as well as Aβs are involved in promoting cell proliferation and survival of NSCs. These observations suggest the potential of beneficial effects of using gangliosides and Aβs for promoting NSC proliferation.
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影响因子：
4.7
作者：
Haughey, NJ;Nath, A;Mattson, MP
通讯作者：
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影响因子：
4.2
作者：
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作者：
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通讯作者：
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