In situ self-assembly of amphiphilic dextran micelles and superparamagnetic iron oxide nanoparticle-loading as magnetic resonance imaging contrast agents.
In situ self-assembly of amphiphilic dextran micelles and superparamagnetic iron oxide nanoparticle-loading as magnetic resonance imaging contrast agents.
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DOI：
10.1093/rb/rbac096
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发表时间：
2023
影响因子：
6.7
通讯作者：
Su, Hongying
中科院分区：
文献类型：
--
作者：
Jiang, Linrui;Zheng, Rong;Zeng, Ni;Wu, Changqiang;Su, Hongying
聚合物胶束由于其纳米级的粒径、生物相容性以及能够负载合理量的货物等优点，一直被认为是疏水药物和成像探针的理想载体。本研究开发了一种简便的葡聚糖胶束制备方法，并对其作为超顺磁性氧化铁纳米晶载体的性能进行了评价。通过氧化葡聚糖与油胺的Schiff碱反应合成了两亲性葡聚糖（Dex-g-OA），并在反应体系中原位自组装成纳米胶束。利用荧光共振能量转移技术，通过检测荧光团对Cy 5和Cy5.5之间的能量转移信号，确定了两亲性葡聚糖的自组装行为。将疏水性SPIO纳米粒子（Fe 3 O 4 NPs）通过原位自组装的方法成功地负载到葡聚糖胶束中，制备了一系列具有良好生物相容性、超顺磁性和T2弛豫增强的Fe 3 O 4 NPs负载胶束纳米复合材料（Fe 3 O 4 @Dex-g-OA）。在0.5 T的磁场下，粒径为116.2 ± 53.7 nm的Fe 3 O 4 @Dex-g-OA纳米复合材料呈现出更高的T2弛豫率，为327.9 ·s-1。所制备的磁性纳米复合材料有望用作磁共振成像中的造影剂。
Polymeric micelles have long been considered as promising nanocarrier for hydrophobic drugs and imaging probes, due to their nanoscale particle size, biocompatibility and ability to loading reasonable amount of cargoes. Herein, a facile method for dextran micelles preparation was developed and their performance as carriers of superparamagnetic iron oxide (SPIO) nanocrystals was evaluated. Amphiphilic dextran (Dex-g-OA) was synthesized via the Schiff base reactions between oxidized dextran and oleylamine, and self-assembled in situ into nano-size micelles in the reaction systems. The self-assembling behaviors of the amphiphilic dextran were identified using fluorescence resonance energy transfer technique by detection the energy transfer signal between the fluorophore pairs, Cy5 and Cy5.5. Hydrophobic SPIO nanoparticles (Fe3O4 NPs) were successfully loaded into the dextran micelles via the in situ self-assembly process, leading to a series of Fe3O4 NPs-loaded micelle nanocomposites (Fe3O4@Dex-g-OA) with good biocompatibility, superparamagnetism and strongly enhanced T2 relaxivity. At the magnetic field of 0.5 T, the Fe3O4@Dex-g-OA nanocomposite with particle size of 116.2 ± 53.7 nm presented a higher T2 relaxivity of 327.9 ·s−1. The prepared magnetic nanocomposites hold the promise to be used as contrast agents in magnetic resonance imaging.
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影响因子：
5.8
作者：
Liu, Mengrui;Du, Hongliang;Zhai, Guangxi
通讯作者：
Zhai, Guangxi
两亲性星状葡聚糖包裹的超顺磁性氧化铁纳米颗粒簇作为有效的磁共振成像探针
影响因子：
14
作者：
Su, Hongying;Liu, Yanhong;Ai, Hua
通讯作者：
Ai, Hua
影响因子：
11.2
作者：
Su, Hongying;Zheng, Rong;Shan, Shaoyun
通讯作者：
Shan, Shaoyun
影响因子：
9.9
作者：
Gómez-Lopera, SA;Plaza, RC;Delgado, AV
通讯作者：
Delgado, AV
影响因子：
3.1
作者：
ISHAK, MF;PAINTER, TJ
通讯作者：
PAINTER, TJ