Perspectives for Forkhead box transcription factors in diabetic cardiomyopathy: Their therapeutic potential and possible effects of salvianolic acids.
Perspectives for Forkhead box transcription factors in diabetic cardiomyopathy: Their therapeutic potential and possible effects of salvianolic acids.
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DOI：
10.3389/fcvm.2022.951597
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发表时间：
2022
影响因子：
3.6
通讯作者：
Xia, Zhengyuan
中科院分区：
文献类型：
--
作者：
Han, Ronghui;Huang, Hemeng;Xia, Weiyi;Liu, Jingjin;Luo, Hui;Tang, Jing;Xia, Zhengyuan
关键词：
糖尿病心肌病（DCM）是糖尿病心血管并发症发病和死亡的主要原因，最初表现为心脏肥大、心肌纤维化、功能失调性重塑和舒张功能障碍，随后出现收缩功能障碍，最终以急性心力衰竭结束。糖尿病心脏病理改变的分子机制是复杂和多因素的，包括但不限于胰岛素抵抗、氧化应激、脂毒性、心肌细胞凋亡或自噬、炎症反应和心肌代谢功能障碍。随着分子生物学技术的发展，越来越多的证据表明O类叉头盒（FoxO）转录因子对维持心肌细胞代谢和细胞存活至关重要，FoxO家族蛋白的功能可以通过多种翻译后修饰来调节，包括磷酸化、乙酰化、泛素化、精氨酸甲基化和O-糖基化。在这篇综述中，我们强调并总结了FoxO家族两个成员的最新进展（主要是FoxO 1和FoxO 3a），其在心脏组织中大量表达，并且其基因和蛋白质表达水平随着DCM进展而变化，目的是提供对糖尿病心血管并发症发病机制的有价值的见解，并讨论其治疗潜力和丹参素酸的可能作用，天然产物。
Diabetic cardiomyopathy (DCM) is the primary cause of morbidity and mortality in diabetic cardiovascular complications, which initially manifests as cardiac hypertrophy, myocardial fibrosis, dysfunctional remodeling, and diastolic dysfunction, followed by systolic dysfunction, and eventually end with acute heart failure. Molecular mechanisms underlying these pathological changes in diabetic hearts are complicated and multifactorial, including but not limited to insulin resistance, oxidative stress, lipotoxicity, cardiomyocytes apoptosis or autophagy, inflammatory response, and myocardial metabolic dysfunction. With the development of molecular biology technology, accumulating evidence illustrates that members of the class O of Forkhead box (FoxO) transcription factors are vital for maintaining cardiomyocyte metabolism and cell survival, and the functions of the FoxO family proteins can be modulated by a wide variety of post-translational modifications including phosphorylation, acetylation, ubiquitination, arginine methylation, and O-glycosylation. In this review, we highlight and summarize the most recent advances in two members of the FoxO family (predominately FoxO1 and FoxO3a) that are abundantly expressed in cardiac tissue and whose levels of gene and protein expressions change as DCM progresses, with the goal of providing valuable insights into the pathogenesis of diabetic cardiovascular complications and discussing their therapeutic potential and possible effects of salvianolic acids, a natural product.
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